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Fig. 6 | BMC Cancer

Fig. 6

From: Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

Fig. 6

The mechanism of emodin enhanced cisplatin-induced cytotoxicity. Emodin can block the chemoresistance of T24 cells to cisplatin through suppression of MRP1. Low dose of emodin can increase the levels of intracellular ROS and deplete the GSH, resulting in enhanced cisplatin-induced cytotoxicity, while high dose of emodin can directly damage the nuclear DNA of cancer cells

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BMC Cancer

ISSN: 1471-2407

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