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Table 2 Differences in FOLR1 mRNA expression and LINE1 DNA hypomethylation according to classical clinico-pathological characteristics

From: Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

   FOLR1 mRNA expressiona LINE1-DNA hypomethylationb
   Median value p-value1 Median value p-value1
Age (median value) Lower 9.96   102.81  
Higher 8.88 0.714 171.82 0.826
G1 VS G2-3 G1 2.55   88.40  
G2-3 10.63 0.010** 138.34 0.436
FIGO stage FIGO I, II 5.28   94.30  
FIGO III, IV 11.94 <0.0001** 151.05 0.305
Residual disease RD = 0 6.45   96.14 0.407
RD > 0 12.64 <0.0001** 152.06  
Histology Serous 14.04   118.29  
Endometrioid 10.24   138.34  
Clear cells 7.60    
Mucinous 2.99 <0.0001** 104.06 0.533
Serous 14.04   118.29  
Non-serous 6.00 <0.0001** 125.62 0.602
Mucinous 2.99   104.06  
Non-mucinous 11.83   125.62 0.337
Platinum response Refractory/resistant 6.82 0.049* 177.82 0.313
Sensitive 11.68   117.71  
Type I/II Type I 5.83   114.84  
Type II 14.59 <0.0001** 134.67 0.345
  1. 1Mann Whitney Test. *Significant at the 0.05 level, **Significant at the 0.01 level, aArbitrary units normalized to TBP, bPUMR values