Skip to main content

Table 1 Results of the logistic regression analysis using LRPath

From: Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells

Gene-set ID # of genes Hits p-Value FDR Regulation Transcription factor
ATF6_01 93 34 2.23 × 10-5 2.69 × 10-3 up ATF6
XBP1_01 152 58 4.27 × 10-5 3.43 × 10-3 up XBP1
E2F_02 96 96 1.05 × 10-14 2.54 × 10-12 down N/A
NFY Q6 26 16 1.06 × 10-3 3.65 × 10-2 down N/A
  1. A ranked list consisting of up- and downregulated genes in HER2/neu-positive SKBR3 cells after palmitate treatment was used as input for a logistic regression pathway analysis (LRPath) to determine enriched transcription factor binding motifs based on the TRANSFAC database. The table shows the two most significantly enriched motifs in the upregulated and downregulated gene groups, as well as the associated transcription factors. N/A indicates that no known transcription factor is associated with this particular motif