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Table 3 Apoptosis associated proteins change in group BF-rTK + GCV.

From: Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors

Gene BF/GCV BF-rTK/GCV Ratio
Bad 100.03 895.52 8.95
Bax 100.15 1155.50a 11.54
Bid 700.90 3450.87 4.92
Bim 100.38 1292.41 12.88
Bcl-2 100.25 1093.11 a 10.90
Bcl-w 100.5 1552.42 15.45
XIAP 463.48 100.25 0.22
Survivin 1047.24 296.30 0.28
Livin 100.38 605.98 6.04
Caspase 3 100.88 1651.20 16.37
Caspase 8 100.57 1256.01 12.49
Cytochrome C 100.35 1004.71 10.01
HtrA2 100.76 1578.36 15.67
c-IAP2 229.05 779.93 3.41
Fas 100.87 789.76 7.83
FasL 100.35 316.53 3.15
TNF-beta 568.88 1408.11 2.48
TRAILR-1 277.23 1306.83 4.71
TRAILR-2 138.21 1055.52 7.64
TRAILR-3 100.35 411.89 4.11
IGF-1 100.32 723.87 7.22
IGF-2 100.77 219.51 2.18
IGFBP-3 142.73 1173.35 8.22
IGFBP-4 96.06 857.88 8.93
IGFBP-5 100.32 760.31 7.58
IGFBP-6 100.33 741.30 7.39
Hsp60 100.35 2263.01 22.56
Hsp70 100.89 2325.38 23.05
Hsp27 100.38 1009.85 10.06
P21 472.51 1305.01 2.76
  1. The boldface letters were anti-apoptosis proteins and the others were apoptosis proteins
  2. The BF value was independent of Table 2 and they are read from two different films
  3. aThe ratio of Bax/Bcl-2 is 1.06
  4. Thirty differential proteins were up-regulated more than 2-fold in group BF-rTK + GCV compared with the BF + GCV intratumor-treated group. To summarize, twenty-three pro-apoptosis associated proteins were increased from 2.48-fold (TNF-β) to more than 23.05-fold (Hsp70). The total of pro-/anti-apoptosis ratio was 5.20-fold and the ratio of Bax/Bcl-2 was 1.06 in group BF-rTK + GCV. The results indicated that BF-rTK + GCV induced the increased expression of many pro-apoptosis associated proteins