Table 2 Summary of in-frame gene fusions
5′ Gene | Location | Direction | 3′ Gene | Location | Direction | Chimera class | Cancer type | Patients no.a |
|---|---|---|---|---|---|---|---|---|
GTF2E2 | chr8:30510950 | - | NGR1 | chr8:32585467 | + | intrachromosomal complex | Â | 1 (PC, LM) |
TMEM66 | chr8:29940363 | - | NGR1 | chr8:32453346 | + | intrachromosomal complex | Identical patient | 4 (PC, LM) |
TNNC2 | chr20:44452630 | - | WFDC3 | chr20:44404241 | - | intrachromosomal complex | 3 (PC, LM) | |
HEPHL1 | chr11:93800911 | + | PANX1 | chr11:93862496 | + | intrachromosomal_NGb | Â | 3 (PC, LM) |
KIAA1984 | chr9:139701518 | + | C9orf86 | chr9:139717977 | + | intrachromosomal_NG | Common fusion | 3 (LM); 4 (PC) |
SLC39A1 | chr1:153933048 | - | CRTC2 | chr1:153927642 | - | intrachromosomal_NG | 2 (PC); 4 (LM) | |
SCNN1A | chr12:6457893 | - | TNFRSF1A | chr12:6443410 | - | intrachromosomal_NG | 3, 5 (PC); 1 (LM) | |
RUVBL1 | chr3:127823674 | - | LDHA | chr11:18424445 | + | interchromosomal complex | Â | 2 (PC) |
TPT1 | chr13:45914237 | - | YBX1 | chr1:43149117 | + | interchromosomal complex | Â | 3 (PC) |
ZMYND8 | chr20:45976600 | - | SEPT9 | chr17:75398141 | + | interchromosomal complex | Â | 3 (PC) |
SOLH | chr16:583998 | + | NOC4L | chr12:132635526 | + | interchromosomal complex | Â | 4 (PC) |
CALR | chr19:13054619 | + | EEF2 | chr19:3981399 | - | intrachromosomal complex | Â | 5 (PC) |
DDX27 | chr20:47855837 | + | ZNFX1 | chr20:47855592 | - | intrachromosomal complex | Â | 3 (PC) |
KIF3B | chr20:30865568 | + | WFDC12 | chr20:43752906 | - | intrachromosomal complex | Â | 1 (PC) |
GSK3B | chr3:119720893 | - | POLQ | chr3:121155122 | - | intrachromosomal complex | Â | 1 (PC) |
CKLF | chr16:66597120 | + | CMTM1 | chr16:66611007 | + | intrachromosomal_NG | Primary specific | 2 (PC) |
DUS4L | chr7:107217037 | + | BCAP29 | chr7:107221204 | + | intrachromosomal_NG | Â | 1 (PC) |
HSPE1 | chr2:198367852 | + | MOBKL3 | chr2:198388348 | + | intrachromosomal complex_NG | Â | 2 (PC) |
PRIM1 | chr12:57127931 | - | NACA | chr12:57118307 | - | intrachromosomal complex_NG | Â | 4 (PC) |
RNF43 | chr17:56494378 | - | SUPT4H1 | chr17:56428869 | - | intrachromosomal_NG | Â | 4 (PC) |
SLC10A3 | chrX:153716020 | - | UBL4A | chrX:153714672 | - | intrachromosomal_NG | Â | 4 (PC) |
UBA2 | chr19:34957919 | + | WTIP | chr19:34981281 | + | intrachromosomal_NG | Â | 5 (PC) |
ZNF606 | chr19:58499575 | - | C19orf18 | chr19:58485571 | - | intrachromosomal_NG | Â | 4 (PC) |
HSP90AA1 | chr14:102551123 | - | NOP58 | chr2:203165075 | + | interchromosomal complex | Â | 1 (LM) |
RPS15A | chr16:18794368 | - | RPL0 | chr8:99057311 | - | interchromosomal complex | Â | 4 (LM) |
FGG | chr4:155526082 | - | ALB | chr4:74285288 | + | intrachromosomal complex | Â | 2 (LM) |
ACE2 | chrX:15582147 | - | PIR | chrX:15509432 | - | intrachromosomal complex | Liver metastases specific | 3 (LM) |
OAF | chr11:120097705 | + | POU2F3 | chr11:120117158 | + | intrachromosomal_NG | Â | 2 (LM) |
SENP3 | chr17:7474797 | + | EIF4A1 | chr17:7477578 | + | intrachromosomal_NG | Â | 4 (LM) |
TGIF2 | chr20:35207369 | + | C20orf24 | chr20:35236118 | + | intrachromosomal_NG | Â | 1 (LM) |