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Table 1 Clinicopathological characteristics of colorectal carcinoma patients and HSP70-2 gene and protein expression

From: Heat shock protein 70–2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth

Clinicopathological features RT-PCR (%) of tissue IHC (%) of tissue  
All tumors 156/200 (78) 156/200 (78)  
Adjacent normal cancerous tissues 0/160 (0) 0/160 (0)  
Tumor stages    
Stage I 6/8 (75) 6/8 (75)  
Stage II 29/37 (79) 29/37 (79)  
Early stages (I + II) 35/45 (78) 35/45 (78)  
Stage III 82/104 (79) 82/104 (79)  
Stage IV 39/51 (76) 39/51 (76)  
Late stages (III + IV) 121/155 (78) 121/155 (78)  
Histologic grades    
Well differentiated 56/71 (79) 56/71 (79)  
Moderately differentiated 81/102 (79) 81/102 (79)  
Poorly differentiated 19/27 (70) 19/27 (70)  
Lymph node involvement    
Positive 121/155 (78) 121/155 (78)  
Negative 35/45 (78) 35/45 (78)  
Metastasis    
Positive 39/51 (76) 39/51 (76)  
Negative 117/149 (79) 117/149 (79)  
Statistical analysis (p values of different test used in this study)
Clinicopathological features Mann-Whitney U-test Pearson’s χ2 test Kruskal-Wallis Test
RT-PCR/IHC RT-PCR/IHC RT-PCR/IHC
ANCT, malignancy 0.0001* 0.0001* -
Tumor Stage    
I + II 0.554 0.835  
II + III 0.152 0.952  
III + IV 0.631 0.737  
I + II & III + IV 0.202 0.967  
I, II, III, and IV - 0.984 0.573
Histological Grade    
WD, MD+ PD - 0.587 0.008*
WD + MD 0.388 0.932  
WD + PD 0.09 0.375  
MD + PD 0.03* 0.268  
Lymph Node Positivity 0.202 0.967  
Metastasis Positivity 0.859 0.760  
  1. IHC immunohistochemistry, MD moderately differentiated, PD poorly differentiated, WD well differentiated
  2. *p < 0.05, statistically significant
  3. Statistical analysis (p values of different test used in this study)