Table 3 H-score, intensity and extent of IHC
IHC | FISH+ | FISH- | Sensitivity | Specificity |
|---|---|---|---|---|
H-score | ||||
≥50 | 10 | 18 | 100 % | 92.1 % |
≥100 | 10 | 5 | 100 % | 97.8 % |
≥150 | 10 | 0 | 100 % | 100.0 % |
≥200 | 5 | 0 | 50.0 % | 100.0 % |
≥250 | 3 | 0 | 30.0 % | 100.0 % |
Intensity | ||||
1+ | 10 | 32 | 100 % | 85.7 % |
2+ | 10 | 1 | 100.0 % | 99.6 % |
3+ | 3 | 0 | 30.0 % | 100 % |
Extent | ||||
≥10 % | 10 | 29 | 100.0 % | 87.28 % |
≥20 % | 10 | 25 | 100.0 % | 89.04 % |
≥30 % | 10 | 20 | 100.0 % | 91.23 % |
≥40 % | 10 | 15 | 100.0 % | 93.42 % |
≥50 % | 10 | 14 | 100.0 % | 93.86 % |
≥60 % | 10 | 9 | 100.0 % | 96.05 % |
≥70 % | 9 | 9 | 90.0 % | 96.05 % |
≥80 % | 7 | 4 | 70.0 % | 98.25 % |
≥90 % | 4 | 1 | 40.0 % | 99.56 % |