Table 2 The characteristics of patients with ROS1 rearrangement
Cases No. | Smokinga | Staging/Gradingb | IHC resultc | H-score | FISH result | Direct sequencing | Histopathology predominant pattern | Staining Pattern | Another gene aberranced |
|---|---|---|---|---|---|---|---|---|---|
1 | N | II B/ Score 5/Grade 2 | 3+/90 % | 260 | Fusion positive | SLC34A2-E4; ROS1-E32/SLC34A2-E4; ROS1-E34 | Acinar | Cytoplasmic; membrane | ALK\EGFR\KRAS(−) |
2 | N | I A/Score 3/Grade 2/ | 2+/65 % | 150 | Fusion positive | CD74-E6; ROS1-E34 | Acinar | Cytoplasmic; focal granular | ALK\EGFR\KRAS(−) |
3 | P | IV/−/− | 2+/70 % | 160 | Fusion positive | CD74-E6; ROS1-E34 | Invasive mucinous adenocarcinoma | Mucinous staining | ALK\EGFR\KRAS(−) |
4 | N | I A/Score 5/Grade 2 | 2+/90 % | 200 | Fusion positive | TPM3-E8; ROS1-E35 | Papillary and acinar | Cytoplasmic; focal granular | ALK\EGFR\KRAS(−) |
5 | N | I A/Socre 5/Grade 3 | 2+/90 % | 200 | Fusion positive | SLC34A2-E14del; ROS1-E32/SLC34A2-E14del; ROS1-E34 | Papillary and micropapillary | Cytoplasmic; focal granular | ALK\EGFR\KRAS(−) |
6 | N | IV/ Socre4/Grade 2 | 3+/85 % | 250 | Fusion positive | CD74-E6; ROS-E34 | Acinar | Cytoplasmic; granular | ALK\EGFR\KRAS(−) |
7e | N | IV/−/− | 2+/70 % | 160 | Fusion positive | – | Invasive adenocarcinoma with acinar pattern | Cytoplasmic; focal granular | ALK\EGFR\KRAS(−) |
8 | S | I A/Score 5/Grade 3 | 3+/90 % | 250 | Fusion positive | – | Papillary and micropapillary | Cytoplasmic; focal granular | ALK\EGFR\KRAS(−) |
9 | S | I B/Socre 3/Grade 2 | 2+/80 % | 180 | Fusion positive | – | Acinar and lepidic | Cytoplasmic; focal granular | ALK\EGFR\KRAS(−) |
10 | N | I B/Score 3/Grade 1 | 2+/80 % | 180 | Fusion positive | – | Lepidic | Cytoplasmic; focal granular | ALK\EGFR\KRAS(−) |