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Table 3 Mean scores of positivity in nucleus and cytoplasm for the clock proteins

From: Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes

Protein Cancer cells Neighbouring mucosa Normal mucosa
Nucleus Cytopl. Nucleus Cytopl. Nucleus Cytopl.
PER 1 2.17 0 1.71 0 2.00 0
+/− SEM 0.15 0 0.10 0 0 0
PER 3 0.22 0.43 0.67 0.73 0 1.15
+/− SEM 0.08 0.11 0.13 0.15 0 0.13
CRY 1 2.08 1.96 1.84 1.27 1.76 0.62
+/− SEM 0.16 0.11 0.14 0.20 0.13 0.15
CRY 2 0 0.83 2.31 2.75 2.00 2.00
+/− SEM 0 0.13 0.23 0.18 0.26 0.28
BMAL1 1.42 2.40 2.33 2.27 1.16 2.08
+/− SEM 0.20 0.12 0.19 0.20 0.21 0.20
CLOCK 2.04 2.23 2.57 2.52 2.75 2.91
+/− SEM 0.16 0.12 0.13 0.13 0.14 0.09
Casein kinase 1 alpha
  1.93 2.70 2.78 3.00 2.90 3.00
+/− SEM 0.18 0.10 0.13 0.00 0.11 0.00
Casein kinase 1 alpha 1 L
  1.96 2.59 2.88 2.96 2.54 2.92
+/−SEM 0.24 0.12 0.08 0.04 0.22 0.08
Casein kinase 1 epsilon
  2.93 2.07 2.75 1.95 3.00 2.00
+/− SEM 0.05 0.05 0.10 0.09 0 0
  1. +/− SEM: +/− standard error of the arithmetic means