The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer

BMC Cancer

Table 5 The results of univariate and multivariate analyses of the expression of Sema4D and PlexinB1, clinicopathological findings and overall survival in the patients with colorectal cancer

	Univariate analysis			Multivariate analysis
Variables	Hazard ratio	95 % CI	p value	Hazard ratio	95 % CI	p value
Gender	0.928	0.574–1.509	0.762
Male vs. Female	0.928	0.574–1.509	0.762
Age	1.365	0.841–2.207	0.205
≧70 vs. <70	1.365	0.841–2.207	0.205
Histology	2.666	1.391–4.373	0.004	1.758	0.901–3.205	0.094
Other vs. well/mod	2.666	1.391–4.373	0.004
Depth of tumor invasion	4.574	2.032–13.08	<0.001	2.692	1.022–9.317	0.044
T3/T4 vs.T1/T2	4.574	2.032–13.08	<0.001
Lymph node metastasis	4.469	2.432–9.017	<0.001	2.304	1.138–5.069	0.019
Positive vs. negative	4.469	2.432–9.017	<0.001
Lymphatic invasion	3.108	1.622–6.725	<0.001	1.318	0.603–3.235	0.505
Positive vs. negative			<0.001
Venus invasion	2.6	1.554–4.25	<0.001	1.409	0.813–2.394	0.216
Positive vs. negative	2.6	1.554–4.25	<0.001
Sema4D and PlexinB1 expression	2.567	1.587–4.158	<0.001	1.681	1.004–2.819	0.047
Both positive vs. others	2.567	1.587–4.158	<0.001

Sema4D semaphorin 4D. Other poorly-differnetiated, mucinous-type, small-cell, signet-cell. CI confidence interval

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