Fig. 1

Immunohistochemical expression in rectal cancer biopsies before neoadjuvant therapy in responder and non responder patients. Pictures show high expression of VRK1 and VRK2 in a responder patient (upper image) and low expression of both proteins in a non responder patient (lower image). Images were taken with a magnification of x200. 1.2. Histograms represent H-score distribution obtained from staining of VRK1 and VRK2 for the whole series of locally advanced rectal cancer patients