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Table 3 Influence of potential prognostic factors on bone survival in multivariate analysis

From: Survival and prognostic factors in patients with stable and unstable spinal bone metastases from solid tumors: a retrospective analysis of 915 cases

  Stable metastases Unstable metastases
Factor Hazard Ratio 95 % CI p-value Hazard Ratio 95 % CI p-value
Age 1.01 0.99–1.02 0.09 1.01 1.00–1.02 0.025
Gender       
 Female Reference      
 Male 1.27 1.01–1.60 0.04 1.07 0.83–1.38 0.59
KPS       
  > =80 % Reference      
  < 80 % 1.27 1.04–1.55 0.02 1.11 0.91–1.35 0.30
Primary site       
 Breast cancer Reference      
 NSCLC 2.77 1.99–3.86 <0.0001 2.00 1.43–2.80 <0.0001
 Renal cancer 0.84 0.53–1.33 0.47 0.85 0.54–1.33 0.47
Localization of metastases       
 Thoracic Reference      
 Lumbar 1.07 0.87–1.31 0.53 0.90 0.73–1.11 0.31
Number of metastases       
 1 Reference      
  > 1 1.16 0.95–1.41 0.13 1.35 1.11–1.65 0.003
Other distant metastases       
 Liver yes Reference      
  no 0.72 0.56–0.92 0.008 0.71 0.54–0.92 0.003
 Brain yes Reference      
  no 0.84 0.63–1.11 0.22 0.85 0.63–1.16 0.32
 Lung yes Reference      
  no 1.27 0.99–1.62 0.06 1.05 0.79–1.40 0.73
 Skin yes Reference      
  no 1.09 0.69–1.72 0.71 0.91 0.44–1.85 0.79
Bisphosphonates       
 yes Reference      
 no 1.19 0.91–1.56 0.21 1.07 0.79–1.44 0.66
Chemotherapy       
 yes Reference      
 no 0.84 0.68–1.02 0.08 0.97 0.79–1.19 0.79
Orthopedic corset       
 yes Reference      
 no 0.84 0.67–1.06 0.14 0.77 0.62–0.96 0.02
Radiotherapy schedule       
  > 30 Gy Reference      
  < =30 Gy 1.27 0.99–1.63 0.06 1.08 0.86–1.35 0.53
  1. Data in bold p-value <0.05 are significant statistically