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Table 5 Assessment of associations between proteins plasma membrane expression and pathological data in CRC primary tumours

From: Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

  MCT1 MCT4 CD147 GLUT1
n Positive (%) p n Positive (%) p n Positive (%) p n Positive (%) p
Tumor size (cm)
 ≤4.5 286 93.4 0.389 278 54.7 0.265 283 27.9 0.003 267 29.6 0.466
 >4.5 182 91.2   175 60.0   180 41.1   167 26.3  
Histological Type
 Adenocarcinoma 417 92.8 0.456 402 57.0 0.862 411 33.6 0.787 386 28.2 0.389
 A. Mucinous 51 90.2   49 57.1   52 28.8   46 26.1  
 A. Invasive 24 95.8   24 54.2   23 26.1   23 39.1  
 Signet ring and mucinous 4 75.0   3 33.3   4 25.0   4 0.0  
Differentiation
 Well-differentiated 219 93.2 0.271 213 56.8 0.070 217 34.6 0.875 202 21.3 0.009
 Moderately-differentiated 209 93.3   204 55.4   206 32.5   197 35.0  
 Poorly-differentiated 49 85.7   43 69.8   48 29.2   43 39.5  
 Undifferentiated 4 100.0   3 0.0   4 25.0   3 33.3  
Tumour Penetration
 Tis 5 100.0 0.946 6 16.7 0.277 4 25.0 0.034 5 0.0 0.436
 T1 30 90.0   28 50.0   30 13.3   27 29.6  
 T2 59 93.2   58 56.9   59 30.5   55 21.8  
 T3 376 92.6   359 57.7   371 33.2   350 29.4  
 T4 24 91.7   25 64.0   24 54.2   20 35.0  
Spread to lymph nodes
 Absent 280 92.5 0.888 272 54.0 0.269 277 32.5 0.876 263 25.5 0.058
 Present 204 92.2   196 59.2   202 33.2   187 33.7  
Vessel invasion
 Absent 159 94.3 0.255 159 58.5 0.541 156 33.3 0.817 150 25.3 0.194
 Present 314 91.4   299 55.5   313 32.3   291 31.3  
TNM
 Stage I 77 92.1 0.566 77 52.0 0.464 77 22.1 0.147 74 23.3 0.206
 Stage II 183 92.9   179 57.0   181 36.5   173 26.0  
 Stage III 155 94.2   151 57.6   154 34.4   142 30.3  
 Stage IV 75 88.0   67 59.7   73 31.5   66 39.4  
BRAF mutations
 Negative 87 94.3 1.000 56 65.9 0.608 33 38.4 0.641 16 19.8 0.196
 Positive (V600E) 4 100   2 50.0   2 50.0   2 50.0  
KRAS mutations (codon12/13 and 61)
 Negative 78 96.3 0.437 51 64.6 0.217 27 34.2 0.668 17 21.8 0.411
 Positive 41 93.2   31 75.6   16 38.1   6 15.4  
Microsatellite Instability
 Negative 102 95.3 0.986 66 65.3 0.335 38 36.5 0.321 20 20.2 0.984
 Positive (MSI-L + MSI-H) 20 95.2   16 76.2   5 25.0   4 20.0