Fig. 1
Random mitochondrial point mutations in-vitro. There was a significantly increased frequency of random mitochondrial DNA mutations in the QH cells (mean 7.710 × 10−5, SD 2.770 × 10−5) (n = 5) compared to HET1A (mean 2.560 × 10−5, SD 1.015 × 10−5) (n = 3), Go (mean 2.730 × 10−5, SD 2.440 × 10−5) (n = 5) and OE33 (mean 2.500 × 10−5, SD 1.430 × 10−5) (n = 5) cells. This demonstrated that random mutations were an early event in this in-vitro model of Barrett’s progression. *p ≤ 0.05