Table 3 Univariate and multivariate analysis of clinicopathological factors with serum osteopontin level (A), serum thrombospondin-1 level (B), serum OPN/TSP-1 ratio (C) for distant metastasis-free survival (DMFS)

Osteopontin

Serum level^a

1.69

1.12–2.56

0.01

1.35

0.93–1.97

0.12

Stage

I to IIIA vs IIIB

0.23

0.12–0.44

<0.0001

0.31

0.15–0.63

0.001

Pleural involvement

Positive vs Negative

2.58

1.50–4.43

<0.001

1.91

1.07–3.40

0.03

Lympho-vascular invasion

Positive vs Negative

2.33

1.37–3.87

0.002

1.80

1.02–3.17

0.04

Adjuvant treatment

No vs Yes

1.20

0.70–2.04

0.54

–

–

–

Age

≥65 vs <65

1.05

0.56–1.97

0.91

–

–

–

Gender

Male vs female

0.97

0.59–1.61

0.92

–

–

–

Smoking history

Smoker vs non-smoker

1

0.51–1.97

1

–

–

–

Thrombospondin-1

Serum level^b

0.39

0.10–1.45

0.23

–

–

–

Stage

I to IIIA vs IIIB

0.23

0.12–0.44

<0.0001

0.29

0.14–0.58

0.001

Pleural involvement

Positive vs Negative

2.58

1.50–4.43

<0.001

1.91

1.07–3.41

0.03

Lympho-vascular invasion

Positive vs Negative

2.33

1.37–3.87

0.002

1.79

1.01–3.14

0.04

Adjuvant treatment

No vs Yes

1.20

0.70–2.04

0.54

–

–

–

Age

≥65 vs <65

1.05

0.56–1.97

0.91

–

–

–

Gender

Male vs female

0.97

0.59–1.61

0.92

–

–

–

Smoking history

Smoker vs non-smoker

1

0.51–1.97

1

–

–

–

OPN/TSP1

Ratio^c

1.31

1.06–1.59

0.01

1.16

0.97–1.40

0.11

Stage

I to IIIA vs IIIB

0.23

0.12–0.44

<0.0001

0.31

0.15–0.63

0.001

Pleural involvement

Positive vs Negative

2.58

1.50–4.43

<0.001

1.90

1.07–3.40

0.03

Lympho-vascular invasion

Positive vs Negative

2.33

1.37–3.87

0.002

1.80

1.02–3.17

0.04

Adjuvant treatment

No vs Yes

1.20

0.70–2.04

0.54

–

–

–

Age

≥65 vs <65

1.05

0.56–1.97

0.91

–

–

–

Gender

Male vs female

0.97

0.59–1.61

0.92

–

–

–

Smoking history

Smoker vs non-smoker

1

0.51–1.97

1

–

–

–