Univariate analysis | Multivariate analysis | ||||||
---|---|---|---|---|---|---|---|
HR | 95 % CI | p value | HR | 95 % CI | p value | ||
A. Factors associated with serum osteopontin level for distant metastasis-free survival | |||||||
Osteopontin | Serum levela | 1.69 | 1.12–2.56 | 0.01 | 1.35 | 0.93–1.97 | 0.12 |
Stage | I to IIIA vs IIIB | 0.23 | 0.12–0.44 | <0.0001 | 0.31 | 0.15–0.63 | 0.001 |
Pleural involvement | Positive vs Negative | 2.58 | 1.50–4.43 | <0.001 | 1.91 | 1.07–3.40 | 0.03 |
Lympho-vascular invasion | Positive vs Negative | 2.33 | 1.37–3.87 | 0.002 | 1.80 | 1.02–3.17 | 0.04 |
Adjuvant treatment | No vs Yes | 1.20 | 0.70–2.04 | 0.54 | – | – | – |
Age | ≥65 vs <65 | 1.05 | 0.56–1.97 | 0.91 | – | – | – |
Gender | Male vs female | 0.97 | 0.59–1.61 | 0.92 | – | – | – |
Smoking history | Smoker vs non-smoker | 1 | 0.51–1.97 | 1 | – | – | – |
B. Factors associated with serum thrombospondin-1 level for distant metastasis-free survival | |||||||
Thrombospondin-1 | Serum levelb | 0.39 | 0.10–1.45 | 0.23 | – | – | – |
Stage | I to IIIA vs IIIB | 0.23 | 0.12–0.44 | <0.0001 | 0.29 | 0.14–0.58 | 0.001 |
Pleural involvement | Positive vs Negative | 2.58 | 1.50–4.43 | <0.001 | 1.91 | 1.07–3.41 | 0.03 |
Lympho-vascular invasion | Positive vs Negative | 2.33 | 1.37–3.87 | 0.002 | 1.79 | 1.01–3.14 | 0.04 |
Adjuvant treatment | No vs Yes | 1.20 | 0.70–2.04 | 0.54 | – | – | – |
Age | ≥65 vs <65 | 1.05 | 0.56–1.97 | 0.91 | – | – | – |
Gender | Male vs female | 0.97 | 0.59–1.61 | 0.92 | – | – | – |
Smoking history | Smoker vs non-smoker | 1 | 0.51–1.97 | 1 | – | – | – |
C. Factors associated with serum osteopontin/thrombospondin-1 ratio for distant metastasis-free survival | |||||||
OPN/TSP1 | Ratioc | 1.31 | 1.06–1.59 | 0.01 | 1.16 | 0.97–1.40 | 0.11 |
Stage | I to IIIA vs IIIB | 0.23 | 0.12–0.44 | <0.0001 | 0.31 | 0.15–0.63 | 0.001 |
Pleural involvement | Positive vs Negative | 2.58 | 1.50–4.43 | <0.001 | 1.90 | 1.07–3.40 | 0.03 |
Lympho-vascular invasion | Positive vs Negative | 2.33 | 1.37–3.87 | 0.002 | 1.80 | 1.02–3.17 | 0.04 |
Adjuvant treatment | No vs Yes | 1.20 | 0.70–2.04 | 0.54 | – | – | – |
Age | ≥65 vs <65 | 1.05 | 0.56–1.97 | 0.91 | – | – | – |
Gender | Male vs female | 0.97 | 0.59–1.61 | 0.92 | – | – | – |
Smoking history | Smoker vs non-smoker | 1 | 0.51–1.97 | 1 | – | – | – |