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Table 1 Results of univariable and multivariable Cox regression models for disease-free survival (DFS)

From: Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma

  Number of Patients Disease-free Survival Time (DFS; median (CI): months) Univariable Multivariable
Hazard ratio (HR) (95% CI) p-value Hazard ratio (HR) (95% CI) p-value
Clinicopathological Parameter
 Age < 64 y. 58 10.2 (6.4 - 13.3) 0.756 (0.508 - 1.122) 0.165   
> 64 y. 60 9.0 (7.3 - 10.9)    
 Gender Female 53 10.9 (8.1 - 13.5) 0.785 (0.528 - 1.161) 0.226   
Male 65 7.8 (6.0 - 11.1)    
 PDAC Location Head 93 9.8 (7.4 - 12.4) 0.564 (0.357 - 0.921) 0.023 0.581 (0.340 - 1.015) 0.056
Body or Tail 25 8.3 (4.4 - 11.1)    
 Tumor diameter < 2 cm 27 13.1 (6.7 - 17.0) 0.676 (0.411 - 1.064) 0.092 0.739 (0.399 - 1.306) 0.306
> 2 cm 91 7.8 (3.3 - 18.9)    
 pG 1 10 13.1 (4.0 - 24.3)   0.715   
2 41 10.2 (7.1 - 16.2)    
3 67 7.7 (6.0 - 11.0)    
 pT 1 2 7.7 (7.3 - 8.1)   0.857   
2 13 11.6 (7.1 - 17.1)    
3 95 9.0 (6.8 - 11.4)    
4 8 8.4 (7.4 - 11.2)    
 pN 0 45 10.3 (6.1 - 13.1) 0.839 (0.557 - 1.248) 0.39   
1 73 8.8 (7.3 - 11.4)    
 pM 0 105 10.0 (7.7 - 12.3) 0.411 (0.230 - 0.802) 0.011 0.441 (0.097 - 1.458) 0.19
1 13 4.7 (3.2 - 10.9)    
 pR 0 91 10.0 (7.8 - 12.4) 0.712 (0.458 - 1.149) 0.159   
1 27 7.7 (7.4 - 11.2)    
 pRM < 1 mm 64 10.0 (6.3 - 13.1) 0.925 (0.621 - 1.382) 0.7   
> 1 mm 50 9.8 (7.0 - 12.3)    
 PNI 0 15 17.1 (3.3 - 56.1) 0.528 (0.264 - 0.955) 0.034 0.516 (0.233 - 1.053) 0.07
1 101 9.8 (7.4 - 11.4)    
 VI 0 36 11.1 (7.0 - 18.9) 0.629 (0.399 - 0.969) 0.035 0.805 (0.485 - 1.303) 0.382
1 76 8.0 (6.4 - 11.0)    
 LVI 0 34 10.2 (6.1 - 14.3) 0.833 (0.529 - 1.276) 0.408   
1 81 8.8 (7.3 - 11.4)    
 ECLNI 0 69 10.4 (7.3 - 13.3) 0.821 (0.544 - 1.254) 0.356   
1 43 8.4 (6.3 - 11.1)    
AJCC TNM Stage 7th Ed. ≤ 2a 38 10.9 (6.8 - 14.3) 0.730 (0.474 - 1.100) 0.134   
≥ 2b 80 8.5 (7.0 - 11.1)     
N0 <T3 M0 (Early) 38 10.9 (6.8 - 14.3) Early vs Adv 0.498 (0.273 - 0.950) Overall 0.104 Overall 0.209
N1 <T3 M0 (LNM) 62 9.8 (7.3 - 12.6)   Early vs Adv 0.035 0.915 (0.295 - 4.022) 0.892
T4 or M1 (Advanced) 18 5 (3.3 - 10.4)     
Adjuvant chemotherapy 0 36 7.4 (4.6 - 11.0) 1.139 (0.733 - 1.728) 0.553   
1 82 10.0 (7.7 - 12.6)    
Molecular Subtypes
 k2 Cluster 1 64 11.6 (7.4 - 16.2) 0.655 (0.440 - 0.976) 0.035 0.252 (0.092 - 0.888) 0.034
Cluster 2 54 7.8 (6.7 - 10.0)    
 k3 Cluster 1 42 13.5 (10.9 - 17.1) Cl1 vs Cl2 0.602 (0.382 - 0.940) Overall 0.053 Overall 0.318
Cluster 2 50 8.0 (7.0 - 10.0) Cl1 vs Cl3 0.615 (0.363 - 1.066) Cl1 vs Cl2 0.026   
Cluster 3 26 4.7 (3.3 - 11.2)   Cl1 vs Cl3 0.082   
 k4 Cluster 1 39 13.3 (9.8 - 16.7) Cl1 vs Cl2 0.670 (0.418 - 1.065) Overall 0.333 Overall 0.751
Cluster 2 45 8.4 (6.7 - 10.0)   Cl1 vs Cl2 0.090   
Cluster 3 7 11.0 (4.8 - 17.1)     
Cluster 4 27 4.7 (3.3 - 11.2)     
 k5 Cluster 1 41 13.5 (10.9 - 17.0) Cl1 vs Cl5 0.488 (0.251 - 1.021) Overall 0.209 Overall 0.616
Cluster 2 35 8.4 (7.0 - 10.2)   Cl1 vs Cl5 0.057   
Cluster 3 4 9.3 (4.8 - NA)     
Cluster 4 26 4.7 (3.3 - 11.2)     
Cluster 5 12 7.5 (4.3 - 11.0)     
  1. Differences between variables or subgroups with a p-value of > 0.1 are not shown in the table and bold fonts indicate significant values (<0.05)