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Table 4 Overall and subgroups meta-analysis of COX-2 rs5275 polymorphism and HNSCC risk

From: COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Overall and subgroups No. OR (95 % CI) Heterogeneity (I2%/p)
C vs. T (unadjusted and adjusted)
 Overall (unadjusted) 4 0.92 (0.81–1.04) 1 %/0.38
 Overall (adjusted) 2 1.06 (0.81–1.40) 0 %/0.33
 HWE (Yes–unadjusted) 3 0.94 (0.82–1.06) 0 %/0.45
 HWE (No–unadjusted) 1 0.69 (0.42–1.11) NA
 Asians (unadjusted) 3 0.97 (0.87–1.16) 17 %/0.30
 Asians (adjusted) 2 1.06 (0.81–1.40) 0 %/0.33
 Caucasian (unadjusted) 1 0.87 (0.74–1.04) NA
 OSCC (unadjusted) 3 0.90 (0.76–1.06) 0 %/0.52
 OSCC (adjusted) 1 0.88 (0.55–1.40) NA
 LSCC (unadjusted) 2 0.88 (0.73–1.06) 47 %/0.17
CC vs. TT (unadjusted and adjusted)
 Overall (unadjusted) 4 0.92 (0.67–1.27) 36 %/0.19
 Overall (adjusted) 4 0.92 (0.67–1.27) 49 %/0.12
 HWE (Yes–unadjusted) 3 0.89 (0.64–1.24) 47 %/0.15
 HWE (No–unadjusted) 1 2.59 (0.31–21.82) NA
 Asians (unadjusted) 3 1.49 (0.87–2.57) 0 %/0.86
 Asians (adjusted) 3 1.45 (0.81–2.59) 16 %/0.30
 Caucasian (unadjusted) 1 0.71 (0.47–1.07) NA
 Caucasian (adjusted) 1 0.75 (0.51–1.10) NA
 OSCC (unadjusted) 3 0.92 (0.59–1.43) 0 %/0.48
 OSCC (adjusted) 3 0.89 (0.56–1.40) 0 %/0.57
 LSCC (unadjusted) 2 0.98 (0.35–2.75) 67 %/0.08
 LSCC (adjusted) 2 0.88 (0.34–2.26) 60 %/0.12
CC vs. CT (unadjusted and adjusted)
 Overall (unadjusted) 4 1.02 (0.74–1.41) 48 %/0.12
 Overall (adjusted) 4 0.99 (0.84–1.16) 0 %/0.60
 HWE (Yes–unadjusted) 3 0.96 (0.68–1.33) 42 %/0.18
 HWE (No–unadjusted) 1 5.13 (0.61–42.88) NA
 Asians (unadjusted) 3 1.73 (0.99–3.01) 0 %/0.54
 Asians (adjusted) 3 0.93 (0.73–1.19) 0 %/0.49
 Caucasian (unadjusted) 1 0.77 (0.52–1.16) NA
 Caucasian (adjusted) 1 1.03 (0.82–1.28) NA
 OSCC (unadjusted) 3 0.99 (0.64–1.53) 44 %/0.17
 OSCC (adjusted) 3 1.02 (0.80–1.30) 28 %/0.25
 LSCC (unadjusted) 2 0.87 (0.54–1.40) 50 %/0.16
 LSCC (adjusted) 2 0.92 (0.70–1.21) 0 %/0.62
CC vs. CT + TT (unadjusted)
 Overall 4 0.96 (0.70–1.31) 43 %/0.15
 HWE (Yes) 3 0.91 (0.66–1.25) 46 %/0.16
 HWE (No) 1 3.65 (0.45–29.89) NA
 Asians 3 1.58 (0.93–2.71) 0 %/0.70
 Caucasian 1 0.74 (0.50–1.09) NA
 OSCC 3 0.94 (0.62–1.43) 16 %/0.30
 LSCC 2 1.02 (0.40–2.60) 63 %/0.10
CC + CT vs. TT (unadjusted and adjusted)
 Overall (unadjusted) 4 0.90 (0.77–1.04) 0 %/0.41
 Overall (adjusted) 3 0.98 (0.84–1.15) 0 %/0.78
 HWE (Yes–unadjusted) 3 0.92 (0.79–1.08) 0 %/0.74
 HWE (No–unadjusted) 1 0.57 (0.30–1.05) NA
 Asians (unadjusted) 3 0.91 (0.74–1.12) 29 %/0.25
 Asians (adjusted) 2 1.00 (0.79–1.27) 0 %/0.49
 Caucasian (unadjusted) 1 0.88 (0.70–1.10) NA
 Caucasian (adjusted) 1 0.97 (0.78–1.20) NA
 OSCC (unadjusted) 3 1.09 (0.55–2.16) 91 %/<0.05
 OSCC (adjusted) 2 1.01 (0.80–1.27) 2 %/0.31
 LSCC (unadjusted) 2 0.87 (0.68–1.10) 7 %/0.30
 LSCC (adjusted) 2 0.89 (0.69–1.15) 0 %/0.35
  1. OSCC oral squamous cell carcinoma; HNSCC head and neck squamous cell carcinoma; LSCC laryngeal squamous cell carcinoma; OR odds ratio; CI confidence interval; NA not available; HWE Hardy–Weinberg Equilibrium