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Table 3 Overall and subgroups meta-analysis of COX-2 rs689466 polymorphism and HNSCC risk

From: COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Overall and subgroups No. OR (95 % CI) Heterogeneity (I2%/p)
A vs. G (unadjusted and adjusted)
 Overall (unadjusted) 5 1.08 (0.97–1.09) 7 %/0.37
 Overall (adjusted) 2 1.07 (0.84–1.36) 0 %/0.88
 Asians (unadjusted) 4 1.12 (1.00–1.25) 0 %/0.56
 Asians (adjusted) 2 1.07 (0.84–1.36) 0 %/0.88
 Caucasian (unadjusted) 1 0.92 (0.73–1.16) NA
 OSCC (unadjusted) 3 1.01 (0.87–1.16) 80 %/0.008
 OSCC (adjusted) 1 1.03 (0.60–1.42) NA
 LSCC (unadjusted) 1 0.96 (0.72–1.32) NA
AA vs. GG (unadjusted)
 Overall 5 1.26 (1.01–1.57) 0 %/0.46
 Asians 4 1.25 (0.99–1.57) 14 %/0.32
 Caucasian 1 1.39 (0.70–2.73) NA
 OSCC 3 1.07 (0.40–2.86) 86 %/<0.05
 LSCC 1 1.30 (0.69–2.45) NA
AA vs. GA (unadjusted and adjusted)
 Overall (unadjusted) 5 1.21 (1.01–1.45) 28 %/0.23
 Overall (adjusted) 4 0.84 (0.69–1.03) 0 %/0.41
 Asians (unadjusted) 4 1.17 (0.97–1.42) 30 %/0.23
 Asians (adjusted) 3 0.89 (0.68–1.16) 23 %/0.27
 Caucasian (unadjusted) 1 1.78 (0.89–3.57) NA
 Caucasian (adjusted) 1 0.79 (0.58–1.07) NA
 OSCC (unadjusted) 3 0.88 (0.53–1.48) 76 %/0.01
 OSCC (adjusted) 2 1.23 (0.23–4.70) 67 %/0.08
 LSCC (unadjusted) 1 1.17 (0.71–1.93) NA
 LSCC (adjusted) 1 1.16 (0.65–2.09) NA
AA vs. GG + GA (unadjusted)
 Overall 5 1.20 (1.01–1.43) 12 %/0.34
 Asians 4 1.18 (0.99–1.41) 26 %/0.26
 Caucasian 1 1.52 (0.78–2.96) NA
 OSCC 3 0.89 (0.50–1.58) 83 %/0.003
 LSCC 1 1.21 (0.75–1.94) NA
AA + GA vs. GG (unadjusted and adjusted)
 Overall (unadjusted) 5 0.98 (0.84–1.15) 28 %/0.23
 Overall (adjusted) 2 0.93 (0.72–1.21) 0 %/0.84
 Asians (unadjusted) 4 1.07 (0.88–1.29) 13 %/0.33
 Asians (adjusted) 2 0.93 (0.72–1.21) 0 %/0.84
 Caucasian 1 0.83 (0.63–1.09) NA
 OSCC (unadjusted) 3 1.03 (0.57–1.88) 75 %/0.02
 OSCC (adjusted) 1 0.78 (0.53–1.14) NA
 LSCC (unadjusted) 1 1.17 (0.68–2.03) NA
 LSCC (adjusted) 1 1.23 (0.71–2.15) NA
  1. OSCC oral squamous cell carcinoma; HNSCC head and neck squamous cell carcinoma; LSCC laryngeal squamous cell carcinoma; OR odds ratio; CI confidence interval; NA not available