Table 3 Overall and subgroups meta-analysis of COX-2 rs689466 polymorphism and HNSCC risk
Overall and subgroups | No. | OR (95 % CI) | Heterogeneity (I2%/p) |
|---|---|---|---|
A vs. G (unadjusted and adjusted) | |||
 Overall (unadjusted) | 5 | 1.08 (0.97–1.09) | 7 %/0.37 |
 Overall (adjusted) | 2 | 1.07 (0.84–1.36) | 0 %/0.88 |
 Asians (unadjusted) | 4 | 1.12 (1.00–1.25) | 0 %/0.56 |
 Asians (adjusted) | 2 | 1.07 (0.84–1.36) | 0 %/0.88 |
 Caucasian (unadjusted) | 1 | 0.92 (0.73–1.16) | NA |
 OSCC (unadjusted) | 3 | 1.01 (0.87–1.16) | 80 %/0.008 |
 OSCC (adjusted) | 1 | 1.03 (0.60–1.42) | NA |
 LSCC (unadjusted) | 1 | 0.96 (0.72–1.32) | NA |
AA vs. GG (unadjusted) | |||
 Overall | 5 | 1.26 (1.01–1.57) | 0 %/0.46 |
 Asians | 4 | 1.25 (0.99–1.57) | 14 %/0.32 |
 Caucasian | 1 | 1.39 (0.70–2.73) | NA |
 OSCC | 3 | 1.07 (0.40–2.86) | 86 %/<0.05 |
 LSCC | 1 | 1.30 (0.69–2.45) | NA |
AA vs. GA (unadjusted and adjusted) | |||
 Overall (unadjusted) | 5 | 1.21 (1.01–1.45) | 28 %/0.23 |
 Overall (adjusted) | 4 | 0.84 (0.69–1.03) | 0 %/0.41 |
 Asians (unadjusted) | 4 | 1.17 (0.97–1.42) | 30 %/0.23 |
 Asians (adjusted) | 3 | 0.89 (0.68–1.16) | 23 %/0.27 |
 Caucasian (unadjusted) | 1 | 1.78 (0.89–3.57) | NA |
 Caucasian (adjusted) | 1 | 0.79 (0.58–1.07) | NA |
 OSCC (unadjusted) | 3 | 0.88 (0.53–1.48) | 76 %/0.01 |
 OSCC (adjusted) | 2 | 1.23 (0.23–4.70) | 67 %/0.08 |
 LSCC (unadjusted) | 1 | 1.17 (0.71–1.93) | NA |
 LSCC (adjusted) | 1 | 1.16 (0.65–2.09) | NA |
AA vs. GG + GA (unadjusted) | |||
 Overall | 5 | 1.20 (1.01–1.43) | 12 %/0.34 |
 Asians | 4 | 1.18 (0.99–1.41) | 26 %/0.26 |
 Caucasian | 1 | 1.52 (0.78–2.96) | NA |
 OSCC | 3 | 0.89 (0.50–1.58) | 83 %/0.003 |
 LSCC | 1 | 1.21 (0.75–1.94) | NA |
AA + GA vs. GG (unadjusted and adjusted) | |||
 Overall (unadjusted) | 5 | 0.98 (0.84–1.15) | 28 %/0.23 |
 Overall (adjusted) | 2 | 0.93 (0.72–1.21) | 0 %/0.84 |
 Asians (unadjusted) | 4 | 1.07 (0.88–1.29) | 13 %/0.33 |
 Asians (adjusted) | 2 | 0.93 (0.72–1.21) | 0 %/0.84 |
 Caucasian | 1 | 0.83 (0.63–1.09) | NA |
 OSCC (unadjusted) | 3 | 1.03 (0.57–1.88) | 75 %/0.02 |
 OSCC (adjusted) | 1 | 0.78 (0.53–1.14) | NA |
 LSCC (unadjusted) | 1 | 1.17 (0.68–2.03) | NA |
 LSCC (adjusted) | 1 | 1.23 (0.71–2.15) | NA |