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Table 1 Characteristics and unadjusted data of included studies

From: COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Study Country (Ethnicity) Form of disease Cases/Control HWE Smoking status Genotyping methods
Sample size Genotype distribution
rs689466 (−1195G > A)   GG GA AA    
 Chiang 2008 China (Asian) OSCC 368/441 80/114 187/235 101/92 Yes Mixed PCR-RFLP
 Peters 2009 Netherlands (Caucasian) HNSCC 431/438 275/260 134/163 22/15 Yes Mixed PCR
 Mittal 2010 India (Asian) OSCC 193/137 3/5 57/32 133/100 Yes Smokers PCR-RFLP
 Chang 2013 China (Asian) HNSCC 313/295 93/90 146/148 74/57 Yes Mixed Taqman
 Niu 2014 China (Asian) HNSCC 259/1035 61/222 126/542 72/271 Yes Mixed Taqman
OSCC 140/1035 44/222 80/542 25/271 Yes Mixed Taqman
LSCC 90/1035 17/222 46/542 27/271 Yes Mixed Taqman
rs5275 (8473 T > C)   TT TC CC    
 Campa 2007 European (multicenter) HNSCC 553/711 252/313 237/321 44/77 Yes Mixed TaqMan
OSCC 252/711 113/313 117/321 22/77 Yes Mixed TaqMan
LSCC 281/711 139/313 120/321 22/77 Yes Mixed TaqMan
 Mittal 2010 India (Asian) OSCC 135/59 74/24 53/34 8/1 No Smokers PCR-RFLP
 Chang 2013 China (Asian) HNSCC 313/295 209/199 89/86 15/10 Yes Mixed Taqman
 Niu 2014 China (Asian) HNSCC 258/1032 177/691 72/316 9/25 Yes Mixed Taqman
OSCC 168/1032 118/691 45/316 5/25 Yes Mixed Taqman
LSCC 90/1032 59/691 27/316 4/25 Yes Mixed Taqman
rs20417 (−765G > C)   GG GC CC    
 Lin 2008 China (Asian) OSCC 297/280 193/107 104/173 0/0 Yes Mixed PCR–RFLP
 Chiang 2008 China (Asian) OSCC 178/205 136/166 42/39 0/0 Yes Mixed PCR–RFLP
 Peters 2009 Netherlands (Caucasian) HNSCC 428/433 321/321 99/99 8/13 Yes Mixed PCR
 Mittal 2010 India (Asian) OSCC 176/96 92/41 78/49 6/6 Yes Smokers PCR–RFLP
 Lakshmi 2012 India (Asian) OSCC 150/150 110/142 28/6 12/2 No Mixed PCR–RFLP
  1. OSCC oral squamous cell carcinoma; HNSCC, head and neck squamous cell carcinoma; LSCC laryngeal squamous cell carcinoma; HWE Hardy–Weinberg Equilibrium