Fig. 9
From: Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models
Proposed mechanism of bile acid action towards cancer progression. 1. Variations in dietary intake play a huge role in determining microbiome composition in the gut. 2. This leads to microbiome modulation of distinct bile acid profiles (CDCA and DCA). 3. Both bile acids destabilise HIF-1α, an important transcription factor involved in the hypoxic switch in tumours and target important anti-cancer phenotypes such as invasion, migration, adhesion and clonogenicity, potentially leading to hypoxic tumour reduction