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Table 5 Analyses of risk factors for HCC recurrence

From: Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

  Univariate analysis Multivariate analysis
HR (95 % CI) P HR (95 % CI) P
Age (>50y vs. ≤ 50y) 0.626 (0.217–1.804) 0.385 N.A.  
Gender (Male vs. Female) 0.886 (0.278–2.827) 0.838 N.A.  
HBsAg (Positive vs. Negative) 1.433 (0.321–6.406) 0.638 N.A.  
Cirrhosis (Positive vs. Negative) 1.323 (0.369–4.743) 0.668 N.A.  
Child-Pugh grade (B vs. A) 0.048 (0.000–23944) 0.700 N.A.  
ALT (>40 U/L vs. ≤ 40 U/L) 0.783 (0.246–2.497) 0.679 N.A.  
AFP (>400 ng/ml vs. ≤ 400 ng/ml) 2.258 (0.756–6.743) 0.145 N.A.  
Tumor number (multiple vs. one) 3.570 (0.998–12.896) 0.052 N.A.  
Tumor size (>5 cm vs. ≤5 cm) 1.094 (0.379–3.154) 0.868 N.A.  
Tumor encapsulation (Yes vs. No) 1.425 (0.477–4.252) 0.526 N.A.  
Satellite lesion (Yes vs. No) 5.726 (1.771–18.509) 0.004 5.917 (1.342–26.078) 0.019
Vascular invasion (Yes vs. No) 2.943 (0.922–9.399) 0.068 N.A.  
Edmondson classification (III-IV vs. I-II) 1.057 (0.354–3.155) 0.921 N.A.  
BCLC stage (B + C vs. 0 + A) 3.496 (0.966–12.646) 0.056 N.A.  
EpCAM+ CTC 2-ΔΔCq (≥2.22 vs. < 2.22) 6.580 (2.056–21.055) 0.001 6.668 (1.943–22.883) 0.003
Treg/CD4+(≥5.07 vs. < 5.07) 2.993 (0.998–8.947) 0.045 0.825 (0.196–3.468) 0.792