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Table 5 Analyses of risk factors for HCC recurrence

From: Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

 

Univariate analysis

Multivariate analysis

HR (95 % CI)

P

HR (95 % CI)

P

Age (>50y vs. ≤ 50y)

0.626 (0.217–1.804)

0.385

N.A.

 

Gender (Male vs. Female)

0.886 (0.278–2.827)

0.838

N.A.

 

HBsAg (Positive vs. Negative)

1.433 (0.321–6.406)

0.638

N.A.

 

Cirrhosis (Positive vs. Negative)

1.323 (0.369–4.743)

0.668

N.A.

 

Child-Pugh grade (B vs. A)

0.048 (0.000–23944)

0.700

N.A.

 

ALT (>40 U/L vs. ≤ 40 U/L)

0.783 (0.246–2.497)

0.679

N.A.

 

AFP (>400 ng/ml vs. ≤ 400 ng/ml)

2.258 (0.756–6.743)

0.145

N.A.

 

Tumor number (multiple vs. one)

3.570 (0.998–12.896)

0.052

N.A.

 

Tumor size (>5 cm vs. ≤5 cm)

1.094 (0.379–3.154)

0.868

N.A.

 

Tumor encapsulation (Yes vs. No)

1.425 (0.477–4.252)

0.526

N.A.

 

Satellite lesion (Yes vs. No)

5.726 (1.771–18.509)

0.004

5.917 (1.342–26.078)

0.019

Vascular invasion (Yes vs. No)

2.943 (0.922–9.399)

0.068

N.A.

 

Edmondson classification (III-IV vs. I-II)

1.057 (0.354–3.155)

0.921

N.A.

 

BCLC stage (B + C vs. 0 + A)

3.496 (0.966–12.646)

0.056

N.A.

 

EpCAM+ CTC 2-ΔΔCq (≥2.22 vs. < 2.22)

6.580 (2.056–21.055)

0.001

6.668 (1.943–22.883)

0.003

Treg/CD4+(≥5.07 vs. < 5.07)

2.993 (0.998–8.947)

0.045

0.825 (0.196–3.468)

0.792