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Table 2 Association of EpCAM+ CTCs with clinical characteristics

From: Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

Clinical characteristics CTC (2-ΔΔCq) P
Low (<2.22) High (≥2.22)
Age (y) ≤50 13 10 0.224
>50 19 7
Sex Female 9 4 0.729
Male 23 13
HBsAg Negative 7 2 0.384
Postive 25 15
HBeAg Negative 24 12 0.586
Postive 8 5
HBVDNA <5*102 21 10 0.703
>5*102 11 7
Child-Pugh score A 32 16 0.166
B 0 1
Liver cirrhosis No 8 4 0.909
Yes 24 13
ALT (U/L) ≤40 19 14 0.103
>40 13 3
AFP (ng/ml) ≤400 28 11 0.060
>400 4 6
Tumor number Single 30 4 0.210
Multiple 2 3
Tumor size (cm) ≤5 18 11 0.566
>5 14 6
Tumor encapsulation Complete 15 6 0.436
None 17 11
Satellite lesion No 30 4 0.210
Yes 2 3
Vascular invasion No 20 5 0.027*
Yes 12 12
Edmondson stage I-II 20 11 0.879
II-IV 12 6
BCLC stage 0 + A 30 14 0.210
B + C 2 3
Treg/CD4+ (%) <5.07 29 11 0.026*
≥5.07 3 6
Early recurrence No 28 7 0.001*
Yes 4 10
  1. p value of < 0.05 was considered statistically-significant