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Fig. 3 | BMC Cancer

Fig. 3

From: New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

Fig. 3

Ertredin derivatives inhibited anchorage-independent growth of NIH3T3/EGFRvIII cells. a Structure of Ertredin. b Inhibitory activity of Ertredin against 3D growth of NIH3T3/EGFRvIII (red solid line) or NIH3T3/EGFRwt (red dashed line), and 2D growth of NIH3T3. Cells were seeded and cultured on ULAS plates (3D) or normal tissue culture plates (2D). Extent of inhibition was detected on day 3. EGF (100 ng/mL) was added to NIH/3 T3/EGFRwt 3D culture. c Structure-activity relationships of Ertredin derivatives

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BMC Cancer

ISSN: 1471-2407

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