Skip to main content

Advertisement

Table 7 Effect of cross-reactivity on the proportion of women with positive and false-positive HPV test results

From: Cross-reactivity profiles of hybrid capture II, cobas, and APTIMA human papillomavirus assays: split-sample study

  HC2   cobas   APTIMA  
  N (%) ≥CIN2 N (%) ≥CIN2 N (%) ≥CIN2
Primary screening, 30–65 years (n = 2859)
 All positive test results 335 (11.7 %) 46 464 (16.2 %) 49 270 (9.4 %) 46
 Samples with high-risk genotypes 262 (9.2 %) 45 357 (12.5 %) 48 221 (7.7 %) 45
 Cross-reacting samples 73 (2.6 %) 1 107 (3.7 %) 1 49 (1.7 %) 1
 False-positive test results, all (%) 289 (10.1 %) 415 (14.5 %) 224 (7.8 %)
 False-positive test results, after exclusion of cross-reactivity (%) 217 (7.6 %) 309 (10.8 %) 176 (6.2 %)
 Proportion of false-positive test results due to cross-reactivity 25 % 26 % 21 %
Referral population (n = 887)
 All positive test results 401 (45.2 %) 124 453 (51.1 %) 123 332 (37.4 %) 112
 Samples with high-risk genotypes 345 (38.9 %) 117 410 (46.2 %) 120 316 (35.6 %) 109
 Cross-reacting samples 56 (6.3 %) 7 43 (4.8 %) 3 16 (1.8 %) 3
 False-positive test results, all (%) 277 (31.2 %) 330 (37.2 %) 220 (24.8 %)
 False-positive test results, after exclusion of cross-reactivity (%) 228 (25.7 %) 290 (32.7 %) 207 (23.3 %)
 Proportion of false-positive test results due to cross-reactivity 18 % 12 % 6 %