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Table 1 Clinical features of the study cohort and the control group

From: Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed

  GN (n = 162) p1 GNBI (n = 55) GN / GNBI (n=217) p 2 NB / GNBN
(n = 591)
Localization       
 Adrenal 51/161 0.613* 15/55 66/216 0.001 * 256/591
31.7 % 27.3 % 30.6 % 43.3 %
 Abdomino-pelvic 67/161   21/55 88/216   211/591
41.6 %   38.2 % 40.7%   35.7 %
 Thoraco-cervical 43/161   19/55 62/216   123/591
26.7 %   34.5 % 28.7 %   20.8 %
INSS-stage       
 Stage 1 112/160 0.404** 35/55 147/215 <0.001 ** 216/591
70.0 % 63.6 % 68.4% 36.5 %
 Stage 2 30/160   16/55 46/215   201/591
18.8 %   29.1 % 21.4%   34.0 %
 Stage 3 18/160   4/55 22/215   174/591
11.3 %   7.3 % 10.2%   29.4 %
Intraspinal tumor 16/162 0.223 9/55 25/217 0.212 89/591
9.9 % 16.4 % 11.5 % 15.1 %
Tumor Volume (median; range) 75 ml
(1.6 – 1100)
0.228 56.9 ml
(1.5 – 871.9)
70.8 ml
(1.5 – 1100)
0.001 49.5 ml
(0.6 – 2300)
Positive mIBG-uptake 27/110 <0.001 22/36 49/146 <0.001 398/444
24.5 % 61.1 % 33.6 % 89.6 %
HVA elevated 45/142 0.001 27/44 72/186 <0.001 327/531
31.7 % 61.4 % 38.7 % 61.6 %
Elevation of HVA above upper limit (median; range) 0.98x
(0.22 - 8.1)
0.137 1.46x
(0.18 – 7.87)
1.1x
(0.18 – 8.1)
0.029 1.5x
(0.25 – 29)
VMA elevated 28/145 <0.001 23/47 51/192 <0.001 345/538
19.3 % 48.9 % 26.6% 64.1 %
Elevation of VMA above upper limit (median; range) 0.71x
(0.17 – 16.1)
0.061 1.3x
(0.21 – 6.7)
0.9x
(0.17 – 16.1)
<0.001 2.1x
(0.24 – 40.3)
NSE elevated 50/124 0.150 22/41 72/165 <0.001 372/487
40.3 % 53.7 % 43.6 % 76.4 %
NSE level (median; range) 18.3 ng/ml
(4.9 – 49.7)
0.706 20.0 ng/ml
(9.5 – 49.0)
19.0 ng/ml
(4.9 – 49.7)
<0.001 37.2 ng/ml
(7 – 2054)
Diagnosis by chance 70/161 0.163 30/55 100/216 0.177 306/591
43.5 % 54,5 % 46.3 % 51.8 %
  1. GN = Ganglioneuroma, GNBI = Ganglioneuroblastoma intermixed, NB = Neuroblastoma, GNBN = Ganglioneuroblastoma nodular,
  2. INSS = International Neuroblastoma Staging System, HVA = homovanillic acid, VMA = vanillylmandelic acid, NSE = neuron specific enolase,
  3. * = adrenal vs. non-adrenal, ** = stage 1 vs. stage 2/3, p1 = p-value GN vs. GNBI, p2 = p-value GN/GNBI vs. NB/GNBN, bold p-values = statistically significant