Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis

Table 4 Kaplan-Meier survival analysis and Multivariate Cox regression analysis for OSCC patients

OSCC	Kaplan-Meier survival analysis unadjusted p-value	Multivariate Cox regression analysis adjusted p-value	Hazard’s ratio (H.R.)	95 % C.I.
Ep-ICD_Nuc ⁺	0.078	0.049	0.35	0.12–0.98
EpEx_Membrane ⁺	0.302	0.189	----	----
Ep-ICD_Nuc + EpEx_Membrane ⁺	0.016	0.003	4.01	1.64–9.83
Age	0.33	0.026	----	----
T classification	0.63	0.913	----	----
Nodal classification	0.041	0.633	----	----
Clinical stage	0.225	0.293	----	----
Extra capsular invasion	<0.001	0.004	4.14	1.56–10.96
Perineural involvement	0.828	0.102	----	----
Vascular involvement	0.355	0.552	----	----

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