Table 1 Clinicopathological characteristics and PIK3CAH1047R mutation status in 86 CRC cases
Category | Total (n) | Direct sequencing | PCR-RFLP | ||
|---|---|---|---|---|---|
| Â | Â | Mutation (%) | P-value | Mutation (%) | P-value |
Number of patients | 86 | 8 (9.3) | Â | 14 (16.3) | Â |
Age (years) | Â | Â | 0.145 | Â | 0.018* |
 >60 | 49 | 7 (14.3) |  | 12 (24.5) |  |
 ≤60 | 37 | 1 (2.7) |  | 2 (5.4) |  |
Gender | Â | Â | 0.275 | Â | 0.498 |
 Male | 53 | 3 (5.7) |  | 7 (13.2) |  |
 Female | 33 | 5 (15.2) |  | 7 (21.2) |  |
Tumor size | Â | Â | 0.924 | Â | 0.702 |
 >5 cm | 47 | 5 (10.6) |  | 7 (14.9) |  |
 ≤5 cm | 39 | 3 (7.7) |  | 7 (17.9) |  |
Tumor location | Â | Â | 0.428 | Â | 0.564 |
 Colon | 37 | 5 (13.5) |  | 7 (18.9) |  |
 Rectum | 49 | 3 (6.1) |  | 7 (14.3) |  |
Tumor differentiation |  |  | 0.001* |  | < 0.0001* |
 Well or Moderate | 67 | 2 (3.0) |  | 4 (6.0) |  |
 Poor | 19 | 6 (31.6) |  | 10 (52.6) |  |
Dukes’ stage |  |  | 1.000 |  | 1.000 |
 A + B | 60 | 6 (10) |  | 10 (16.7) |  |
 C + D | 26 | 2 (7.7) |  | 4 (15.4) |  |
Lymph node metastasis | Â | Â | 0.603 | Â | 0.708 |
 + | 34 | 2 (5.9) |  | 4 (11.8) |  |
 − | 69 | 6 (8.7) |  | 10 (14.5) |  |