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Fig. 1 | BMC Cancer

Fig. 1

From: The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model

Fig. 1

Effect of LTD4 and PGE2 on xenograft tumor growth initiated by ALDH+ HCT-116 cells. Mice were injected subcutaneously with 1 × 104 ALDH+ HCT-116 cells into two flanks and received subcutaneous injections of vehicle (5 % ethanol in PBS), LTD4 (24.8 μg/kg/day) or PGE2 (17.6 μg/kg/day) from the third week onwards daily. a Images of xenograft mice with representative tumor sizes upon daily administration of either ethanol, LTD4 or PGE2 at day 48. b Graph showing tumor volume for the mice treated with vehicle (ethanol), LTD4 or PGE2. c Representative tumor images from treated groups at the experimental end-point, day 48. d Tumor weights of the LTD4- and PGE2-treated groups compared with the vehicle group at the end-point, day 48. The data shown are the means ± SEM, n = 6 mice in each group. *P < 0.05, **P < 0.01

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