Fig. 2

The effects of Dp on the carcinogens-induced chronic cellular breast carcinogenesis. MCF10A cells were treated with carcinogens NNK and B[a]P or co-treated with carcinogens and Dp (10, 20 and 40 μM respectively) for 30 days. Then cancer-associated properties were evaluated by RDGF assay (a), AIG assay (b) and scratch/wound healing assay (c) in MDA-MB-231 (M231), MCF-7 (M7), MCF10A (M10A), 30-d carcinogens-treated MCF10A cells (CarT), and 30-d carcinogens plus Dp co-treated MCF10A cells (CarT-Dp). The data are presented as the means ± SD (n = 3). ^* P < 0.05 and ^** P < 0.01 compared with MCF10A cells; ^# P < 0.05 and ^## P < 0.01 compared with CarT cells; &P < 0.05; &&P < 0.01 compared with cells in 12 h