Table 3 Number and site of metastases in the patients treated with a pemetrexed-containing therapy
Total (n = 314) | Good responder (n = 92) | Poor responder (n = 222) | P-value | |
|---|---|---|---|---|
Number of metastatic sites ≥2 | 201 (64.0) | 44 (47.8) | 157 (70.7) | <0.001 |
Site of metastases | ||||
Lung | 152 (48.4) | 48 (52.2) | 104 (46.8) | 0.390 |
Pleura | 144 (45.9) | 39 (42.4) | 105 (47.3) | 0.427 |
Bone | 125 (39.8) | 29 (31.5) | 96 (43.2) | 0.053 |
Brain | 77 (24.5) | 18 (19.6) | 59 (26.6) | 0.189 |
Adrenal gland | 45 (14.3) | 3 (3.3) | 42 (18.9) | <0.001 |
Liver | 43 (13.7) | 5 (5.4) | 38 (17.1) | 0.006 |
Pericardial effusion | 20 (6.4) | 5 (5.4) | 15 (6.8) | 0.662 |
Previous surgical therapy | 68 (21.7) | 37 (40.2) | 31 (14.0) | <0.001 |