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Table 4 Association between the clinicopathological variables and EGFR/HER2 protein expression or gene amplification (N = 220)

From: EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus

  EGFR IHC staining intensity, N (%) EGFR in situ hybridisation status, N (%) HER2 IHC staining intensity, N (%) HER2 in situ hybridisation status, N (%)
  0/1+ 2+/3+ P valuea EGFR gene amplification No EGFR gene amplification P valuea 0/1+ 2+/3+ P valuea HER2 gene amplification No HER2 gene amplification P valuea
Patient gender
 Female 59 (39.9) 20 (27.8) NS 8 (25.8) 71 (37.6) NS 69 (36.5) 10 (32.3) NS 8 (27.6) 71 (37.2) NS
 Male 89 (60.1) 52 (72.2)   23 (74.2) 118 (62.4)   120 (63.5) 21 (67.7)   21 (72.4) 120 (62.8)  
Site of primary tumour
 Distal oesophagus/GOJ/cardia 49 (33.1) 34 (47.2) NS 18 (58.1) 65 (34.4) 0.016 69 (36.5) 14 (45.2) NS 14 (48.3) 69 (36.1) NS
 Corpus/antrum/pylorus 99 (66.9) 38 (52.8)   13 (41.9) 124 (65.6)   120 (63.5) 17 (54.8)   15 (51.7) 122 (63.9)  
Histological differentiation grade
 Grade I 23 (15.5) 7 (9.7) NS 2 (6.5) 28 (14.8) NS 28 (14.8) 2 (6.5) NS 2 (6.9) 28 (14.7) NS
 Grade II 71 (48.0) 32 (44.4)   17 (54.8) 86 (45.5)   83 (43.9) 20 (64.5)   18 (62.1) 85 (44.5)  
 Grade III 54 (36.5) 33 (45.8)   12 (38.7) 75 (39.7)   78 (41.3) 9 (29.0)   9 (31.0) 78 (40.8)  
Postoperative Tb
 pT1–pT2 54 (37.0) 15 (21.4) 0.029 4 (13.31) 65 (34.9) 0.020 63 (34.1) 6 (19.4) NS 6 (20.7) 63 (33.7) NS
 pT3–pT4 92 (63.0) 55 (78.6)   26 (86.7) 121 (65.1)   122 (65.9) 25 (80.6)   23 (79.3) 124 (66.3)  
Postoperative stage
 I–II 100 (67.6) 42 (58.3) NS 14 (45.2) 128 (67.7) 0.024 125 (66.1) 17 (54.8) NS 15 (51.7) 127 (66.5) NS
 III–IV 48 (32.4) 30 (41.7)   17 (54.8) 61 (32.3)   64 (33.9) 14 (45.2)   14 (48.3) 64 (33.5)  
  1. aFisher’s exact test
  2. b N = 216, the depth of tumour invasion could not be determined for four patients not receiving surgical treatment