Fig. 1From: EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagusThe association between EGFR/HER2 protein expression and EGFR/HER2 gene amplification in two intestinal-type oesophagogastric adenocarcinomas. Figures a–d show the same area in a single tumour: a Strong (3+) membranous EGFR protein expression (IHC), b negative HER2 protein expression and c–d EGFR gene amplification (SISH). Figures e–h show the same area in another tumour: e Negative EGFR protein expression (IHC), (f) strong (3+) membranous HER2 protein expression and g–h HER2 gene amplification (SISH). Original objective magnification 10x and 60x. IHC, immunohistochemistry; SISH, silver in situ hybridisationBack to article page