Fig. 3

Exogenous expression of the Androgen Receptor. a The human androgen receptor (AR) is mapped to the proximal long arm of the X-chromosome (Xq11-12). The eight exons that encode the human AR protein are separated by introns of various lengths. Like other nuclear receptors, the AR protein consists of several functional domains such as the N-Terminal Domain (NTD), DNA-Binding Domain (DBD), the hinge region and the Ligand-Binding Domain (LBD). The pLENTI6.3/AR-GC-E2325 vector contains the human cytomegalovirus (CMV) immediate early promoter that allows for high-level, constitutive expression of the AR gene. The figure is adapted from [75]. b RT-qPCR and c Western Blot of AR in cells transduced with the AR in cultures ± 1 nM R1881 for 48 hours. Error bars show 95 % confidence intervals. RQ = relative quantity. N.D. = not detected