Table 1 Tamoxifen-resistant cells develop individual as well as common drug sensitivities and co-resistances. Sensitizing and desensitizing drugs, drug target classes, specific target genes and as well as affected cell lines are listed
Sensitivity towards | Drug target class | Specific target gene | Observed in cell line |
|---|---|---|---|
Navitoclax, Obatoclax | BCL-family | BCL2L1 | T-47D Tam1 |
BAD | |||
RAF265, Ponatinib | RAF-family | RAF1 | T-47D Tam1 |
Dasatinib, KX2-391 | SRC/ABL | ABL1 | T-47D Tam1 & Tam2 |
SRC | |||
VX-11E | MAPK1 | MAPK1 | T-47D Tam2, BT-474 Tam2, ZR-75-1 Tam2 |
Gefitinib, Ibrutinib, Neratinib, Nintedanib | HER2/EGFR | ERBB2 | BT-474 Tam1 & Tam2 |
ERBB4 | |||
ERBB3 | |||
Vinblastine | Tubulins | TUBA1A | T-47D Tam2 |
TUBA4A | |||
TUBA1C | |||
TUBB6 | |||
PF-3845 | FAAH | FAAH | ZR-75-1 Tam2 |
Bortezomib | PSMB-family | PSMB5 | ZR-75-1 Tam2 |
Resistance towards | Drug target class | Specific target gene | Observed in cell line |
YM155 | BIRC5 | BIRC5 | T-47D Tam1 & Tam2, MCF-7 Tam1, BT-474 & Tam2 |
Quisinostat, Panobinostat | HDACs | HDAC1 | T-47D Tam2, MCF-7 Tam1 |
HDAC6 | |||
Docetaxel, Paclitaxel | Tubulins | TUBA1C | BT-474 Tam2 |
TUBB2A | |||
TUBB3 | |||
TUBB | |||
TUBB4B | |||
TUBB6 | |||
Temsirolimus, Everolimus, Ridaforolimus, INK128, Sirolimus, AZD8055, Dactolisib | mTOR | mTOR | MCF-7 Tam1 |