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Table 4 Corresponding study data and clinical charcteristics of patients

From: A phase I trial of the trifunctional anti Her2 × anti CD3 antibody ertumaxomab in patients with advanced solid tumors

No.

Age range

Tumor

ECOG PS

No. of prior CHT

Organs involved

Her2 Status1

Dose level

No. of cycles

Best response

01

70–80

Rectum

1

4

LN, PUL, HEP, ADR

IHC 3+

1

2

SD

02

70–80

Head and neck

1

3

LN, PUL

IHC 3+

1

2

SD

03

40–50

Rectum

0

3

LN, SPLEEN, BLADDER, ABDOM WALL

IHC 3+

1

1

PD

04

60–70

Pancreas

1

3

ABDOM WALL

IHC 2+, ISH +

5

1

PD

05

50–60

Breast

0

4

PUL, OSS, LYMPHANG

IHC 3+

5

0

ND

06

50–60

Breast

0

3

HEP

IHC 3+

5

2

PR

07

50–60

Rectum

1

3

LN, PUL, PLEU, ABDOM WALL, PERI

IHC 2+, ISH+

5

1

PD

08

40–50

Stomach

0

4

LN

IHC 3+

9

1

PD

09

50–60

Breast

0

3

CHEST WALL, CEREB, HEP, OSS

IHC 3+

9

1

PD

10

50–60

Breast

0

4

LN, CUT

IHC 3+

9

1

PD

11

60–70

Head and neck

1

4

PUL, PLEU, OS

IHC 3+

13

1

PD

12

50–60

Stomach

0

4

PERI, OVAR

IHC 3+

13

1

PD

13

30–40

Breast

0

4

CUT

IHC 3+

13

1

PD

14

50–60

Stomach

1

1

LN

IHC 2+

13

1

PD