Table 1 Dose escalation scheme
Dose level | Escalation scheme [μg] | No. of pts |
|---|---|---|
1 a | 10-50-100-100-100 | 3–6 |
2 | 10-50-100-100-150 | 3–6 |
3 | 10-50-100-150-150 | 3–6 |
4 | 20-50-100-150-150 | 3–6 |
5 a | 20-50-100-150-200 | 3–6 |
6 | 20-50-100-150-250 | 3–6 |
7 | 20-50-100-200-200 | 3–6 |
8 | 50-100-150-200-200 | 3–6 |
9 a | 20-50-100-200-300 | 3–6 |
10 | 20-50-100-200-350 | 3–6 |
11 | 50-100-100-150-200 | 3–6 |
12 | 50-100-150-200-200 | 3–6 |
13 a | 50-100-150-200-300 | 3–6 |
14 | 50-100-150-300-300 | 3–6 |
15 | 50-150-150-300-300 | 3–6 |
16 | 50-150-300-400-500 | 3–6 |