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Table 3 Multivariate Cox regression analyses (Stepwise procedure)

From: Serum HER2 extra-cellular domain, S100ß and CA 15-3 levels are independent prognostic factors in metastatic breast cancer patients

Parameter Hazard-ratio 95 % CI P-value
Performance status:
 ECOG 0 1   
 ECOG 1 1.75 1.12–2.73 0.013
 ECOG 2 2.62 1.51–4.53 0.001
 ECOG 3 9.78 4.85–19.73 <0.001
Tumor biology:
 HER2+/HR+ 1   
 HER2+/HR− 1.19 0.70–2.04 0.514
 HER2−/HR+ 2.49 1.49–4.18 0.001
 Triple negative 5.31 2.97–9.47 <0.001
Number of previous metastatic CT lines:
 0 1   
 1 or 2 1.81 1.14–2.86 0.012
 > 2 2.57 1.57–4.21 <0.001
Brain metastases 2.26 1.57–3.25 <0.001
Subcutaneous metastases 1.92 1.22–3.01 0.005
Elevated CA 15-3 (cut-off 30 UI/L) 1.95 1.31–2.93 0.001
Elevated HER2 ECD (cut-off 30 ng/mL) 2.51 1.53–4.12 <0.001
Elevated S100ß (cut-off 0.12 μg/L) 1.93 1.05–3.54 0.033
  1. Abbreviations: ECOG Eastern Cooperative Oncology Group, CT chemotherapy, CA 15-3 Cancer Antigen 15-3, HER2-ECD HER2-extra-cellular domain