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Table 3 Multivariable analysis (After Matching) of factors associated with overall survival

From: Poor survival in stage IIB/C (T4N0) compared to stage IIIA (T1-2 N1, T1N2a) colon cancer persists even after adjusting for adequate lymph nodes retrieved and receipt of adjuvant chemotherapy

Variable HR 95 % CI P-value
Stage
 Stage IIB/C 1.52 (1.44,1.60) <.0001
 Stage IIIA 1.00
Age
 18–49
 50–64 1.24 (1.06, 1.44) 0.006
 65–74 1.70 (1.44, 1.99) <.0001
 75 and more 2.85 (2.43, 3.35) <.0001
Race/Ethnicity
 White 1.00
 Black 1.18 (1.09, 1.28) <.0001
 American Indian, Aleutian, or Eskimo 1.15 (0.71, 1.87) 0.57
 Asian or Pacific Islander 0.76 (0.62, 0.94) 0.01
 Other 0.73 (0.45, 1.18) 0.20
Facility Type
 Community cancer program 1.29 (1.18, 1.40) <.0001
 Comprehensive community cancer center 1.15 (1.08, 1.22) <.0001
 Academic research program 1.00
Facility Location
 New England 1.00 (0.88, 1.14) 0.98
 Mid Atlantic 0.99 (0.90, 1.10) 0.91
 South Atlantic 0.95 (0.87, 1.05) 0.32
 East North Central 0.95 (0.87, 1.05) 0.31
 East South Central 0.98 (0.87, 1.11) 0.79
 West North Central 1.02 (0.91, 1.15) 0.68
 West South Central 0.96 (0.85, 1.08) 0.46
 Mountain 0.91 (0.79, 1.06) 0.25
 Pacific 1.00
Urban/Rural Location
 Metro ≥1 million 1.00
 Metro 250 k to 1 million 1.02 (0.96, 1.08) 0.56
 Urban <250 k 0.95 (0.87, 1.03) 0.22
 Urban ≥ 20 k adjacent metro 0.98 (0.87, 1.11) 0.75
 Urban ≥ 20 k not adjacent metro 0.89 (0.73, 1.08) 0.24
 Urban <20 k adjacent metro 0.98 (0.87, 1.10) 0.68
 Urban <20 k not adjacent metro 1.10 (0.94, 1.28) 0.25
 Rural <2500 adjacent metro 0.93 (0.72, 1.21) 0.57
 Rural <2500 not adjacent metro 0.90 (0.71, 1.14) 0.38
Comorbidities
 0 1.00
 1 1.26 (1.19, 1.33) <.0001
 2 1.65 (1.53, 1.77) <.0001
Primary Site
 Cecum 1.00
 Ascending Colon 1.00 (0.93, 1.08) 0.99
 Hepatic Flexure 1.02 (0.90, 1.16) 0.72
 Transverse Colon 0.97 (0.88, 1.06) 0.45
 Splenic Flexure 1.16 (0.99, 1.35) 0.07
 Descending Colon 1.06 (0.95, 1.19) 0.31
 Sigmoid Colon 0.98 (0.92, 1.05) 0.58
 Overlapping Lesions 0.92 (0.70, 1.20) 0.54
 Not Otherwise Specified 1.39 (1.17, 1.66) 0.0002
Readmission within 30 days of Surgery
 Not readmitted 1.00
 Readmitted 1.21 (1.12, 1.31) <.0001
Grade
 Well differentiated 1.00
 Moderately differentiated 1.07 (0.98, 1.16) 0.12
 Poorly differentiated 1.20 (1.09, 1.32) 0.0002
 Undifferentiated, anaplastic 1.21 (1.00, 1.47) 0.05
Regional Lymph Nodes Examined
 0–11 1.30 (1.23, 1.37) <.0001
 12–90 1.00
Chemotherapy
 Yes 1.00
 No 2.24 (2.11, 2.37) <.0001
Surgical Margins
 No residual tumor 1.00
 With Residual tumor 1.56 (1.29, 1.89) 0.003