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Table 4 Hazard ratios and 95 % confidence intervals for CRC-specific mortality by pre-diagnostic weight change

From: Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

 

Weight change (kg)

 
 

≤−2

−1.9–1.9

2.0–7.9

≥8.0

Per 5 kga

Ptrendb

MEN

 CRC, n = 999

  Person-years

836

1844

2240

694

  

  Number of CRC-related deaths

67

109

144

52

  

  HR (95 % CI)c

1.27 (0.93, 1.74)

1 (Ref)

0.95 (0.73, 1.23)

0.93 (0.65, 1.32)

1.01 (0.87, 1.19)

0.86

 Colon cancer, n = 637

  Person-years

505

1043

1454

360

  

  Number of CRC-related deaths

38

70

92

35

  

  HR (95 % CI)c

0.96 (0.64, 1.44)

1 (Ref)

0.81 (0.59, 1.13)

1.02 (0.66, 1.58)

1.05 (0.86, 1.28)

0.62

 Proximal colon cancer, n = 339

  Person-years

304

438

833

120

  

  Number of CRC-related deaths

14

38

52

19

  

  HR (95 % CI)c

0.59 (0.31, 1.12)

1 (Ref)

0.66 (0.42, 1.05)

0.77 (0.40, 1.48)

0.88 (0.63, 1.23)

0.46

 Distal colon cancer, n = 270

  Person-years

195

576

575

224

  

  Number of CRC-related deaths

19

28

33

14

  

  HR (95 % CI)c

1.53 (0.80, 2.93)

1 (Ref)

0.95 (0.55, 1.62)

1.50 (0.75, 3.00)

1.25 (0.94, 1.66)

0.13

 Rectal cancer, n = 351

  Person-years

330

798

737

325

  

  Number of CRC-related deaths

28

39

51

17

  

  HR (95 % CI)c

1.78 (1.06, 3.00)

1 (Ref)

1.21 (0.78, 1.87)

0.76 (0.40, 1.44)

0.95 (0.74, 1.23)

0.70

WOMEN

 CRC, n = 895

  Person-years

1049

1562

2034

646

  

  Number of CRC-related deaths

72

91

119

44

  

  HR (95 % CI)c

1.14 (0.82, 1.59)

1 (Ref)

1.33 (1.01, 1.76)

1.41 (0.97, 2.05)

1.18 (1.01, 1.37)

0.03

 Colon cancer, n = 608

  Person-years

670

1124

1270

473

  

  Number of CRC-related deaths

49

53

85

30

  

  HR (95 % CI)c

1.34 (0.88, 2.02)

1 (Ref)

1.54 (1.08, 2.20)

1.64 (1.03, 2.63)

1.22 (1.02, 1.45)

0.03

 Proximal colon cancer, n = 383

  Person-years

423

673

645

247

  

  Number of CRC-related deaths

32

33

50

18

  

  HR (95 % CI)c

1.28 (0.76, 2.16)

1 (Ref)

1.59 (1.01, 2.49)

1.49 (0.81, 2.75)

1.18 (0.95, 1.47)

0.14

 Distal colon cancer, n = 207

  Person-years

231

449

579

197

  

  Number of CRC-related deaths

15

18

29

12

  

  HR (95 % CI)c

1.52 (0.71, 3.25)

1 (Ref)

1.34 (0.69, 2.60)

2.99 (1.27, 7.05)

1.40 (1.01, 1.95)

0.04

 Rectal cancer, n = 283

  Person-years

379

438

721

173

  

  Number of CRC-related deaths

23

37

34

14

  

  HR (95 % CI)c

0.93 (0.52, 1.64)

1 (Ref)

1.00 (0.60, 1.69)

1.29 (0.67, 2.49)

1.12 (0.82, 1.53)

0.49

  1. a Analyses restricted to cases who maintained or gained weight
  2. b Wald P-value for weight gain as continuous variable
  3. c Stratified Cox model (year of diagnosis: < 1990, 1990–1994, 1995–1999, 2000–2004, ≥2005). Adjustment for age at diagnosis, stage of disease at diagnosis (localized, regional, distant), smoking (never, former, or current), physical activity level (sedentary, moderately active, or active), education (≤9, 10–12, or ≥13 years), and initial BMI (continuous)
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BMC Cancer

ISSN: 1471-2407

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