Weight change (kg) | ||||||
---|---|---|---|---|---|---|
≤−2 | −1.9–1.9 | 2.0–7.9 | ≥8.0 | Per 5 kga | Ptrendb | |
MEN | ||||||
CRC, n = 999 | ||||||
Person-years | 836 | 1844 | 2240 | 694 | ||
Number of CRC-related deaths | 67 | 109 | 144 | 52 | ||
HR (95 % CI)c | 1.27 (0.93, 1.74) | 1 (Ref) | 0.95 (0.73, 1.23) | 0.93 (0.65, 1.32) | 1.01 (0.87, 1.19) | 0.86 |
Colon cancer, n = 637 | ||||||
Person-years | 505 | 1043 | 1454 | 360 | ||
Number of CRC-related deaths | 38 | 70 | 92 | 35 | ||
HR (95 % CI)c | 0.96 (0.64, 1.44) | 1 (Ref) | 0.81 (0.59, 1.13) | 1.02 (0.66, 1.58) | 1.05 (0.86, 1.28) | 0.62 |
Proximal colon cancer, n = 339 | ||||||
Person-years | 304 | 438 | 833 | 120 | ||
Number of CRC-related deaths | 14 | 38 | 52 | 19 | ||
HR (95 % CI)c | 0.59 (0.31, 1.12) | 1 (Ref) | 0.66 (0.42, 1.05) | 0.77 (0.40, 1.48) | 0.88 (0.63, 1.23) | 0.46 |
Distal colon cancer, n = 270 | ||||||
Person-years | 195 | 576 | 575 | 224 | ||
Number of CRC-related deaths | 19 | 28 | 33 | 14 | ||
HR (95 % CI)c | 1.53 (0.80, 2.93) | 1 (Ref) | 0.95 (0.55, 1.62) | 1.50 (0.75, 3.00) | 1.25 (0.94, 1.66) | 0.13 |
Rectal cancer, n = 351 | ||||||
Person-years | 330 | 798 | 737 | 325 | ||
Number of CRC-related deaths | 28 | 39 | 51 | 17 | ||
HR (95 % CI)c | 1.78 (1.06, 3.00) | 1 (Ref) | 1.21 (0.78, 1.87) | 0.76 (0.40, 1.44) | 0.95 (0.74, 1.23) | 0.70 |
WOMEN | ||||||
CRC, n = 895 | ||||||
Person-years | 1049 | 1562 | 2034 | 646 | ||
Number of CRC-related deaths | 72 | 91 | 119 | 44 | ||
HR (95 % CI)c | 1.14 (0.82, 1.59) | 1 (Ref) | 1.33 (1.01, 1.76) | 1.41 (0.97, 2.05) | 1.18 (1.01, 1.37) | 0.03 |
Colon cancer, n = 608 | ||||||
Person-years | 670 | 1124 | 1270 | 473 | ||
Number of CRC-related deaths | 49 | 53 | 85 | 30 | ||
HR (95 % CI)c | 1.34 (0.88, 2.02) | 1 (Ref) | 1.54 (1.08, 2.20) | 1.64 (1.03, 2.63) | 1.22 (1.02, 1.45) | 0.03 |
Proximal colon cancer, n = 383 | ||||||
Person-years | 423 | 673 | 645 | 247 | ||
Number of CRC-related deaths | 32 | 33 | 50 | 18 | ||
HR (95 % CI)c | 1.28 (0.76, 2.16) | 1 (Ref) | 1.59 (1.01, 2.49) | 1.49 (0.81, 2.75) | 1.18 (0.95, 1.47) | 0.14 |
Distal colon cancer, n = 207 | ||||||
Person-years | 231 | 449 | 579 | 197 | ||
Number of CRC-related deaths | 15 | 18 | 29 | 12 | ||
HR (95 % CI)c | 1.52 (0.71, 3.25) | 1 (Ref) | 1.34 (0.69, 2.60) | 2.99 (1.27, 7.05) | 1.40 (1.01, 1.95) | 0.04 |
Rectal cancer, n = 283 | ||||||
Person-years | 379 | 438 | 721 | 173 | ||
Number of CRC-related deaths | 23 | 37 | 34 | 14 | ||
HR (95 % CI)c | 0.93 (0.52, 1.64) | 1 (Ref) | 1.00 (0.60, 1.69) | 1.29 (0.67, 2.49) | 1.12 (0.82, 1.53) | 0.49 |