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Table 4 Hazard ratios and 95 % confidence intervals for CRC-specific mortality by pre-diagnostic weight change

From: Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

  Weight change (kg)  
  ≤−2 −1.9–1.9 2.0–7.9 ≥8.0 Per 5 kga Ptrendb
MEN
 CRC, n = 999
  Person-years 836 1844 2240 694   
  Number of CRC-related deaths 67 109 144 52   
  HR (95 % CI)c 1.27 (0.93, 1.74) 1 (Ref) 0.95 (0.73, 1.23) 0.93 (0.65, 1.32) 1.01 (0.87, 1.19) 0.86
 Colon cancer, n = 637
  Person-years 505 1043 1454 360   
  Number of CRC-related deaths 38 70 92 35   
  HR (95 % CI)c 0.96 (0.64, 1.44) 1 (Ref) 0.81 (0.59, 1.13) 1.02 (0.66, 1.58) 1.05 (0.86, 1.28) 0.62
 Proximal colon cancer, n = 339
  Person-years 304 438 833 120   
  Number of CRC-related deaths 14 38 52 19   
  HR (95 % CI)c 0.59 (0.31, 1.12) 1 (Ref) 0.66 (0.42, 1.05) 0.77 (0.40, 1.48) 0.88 (0.63, 1.23) 0.46
 Distal colon cancer, n = 270
  Person-years 195 576 575 224   
  Number of CRC-related deaths 19 28 33 14   
  HR (95 % CI)c 1.53 (0.80, 2.93) 1 (Ref) 0.95 (0.55, 1.62) 1.50 (0.75, 3.00) 1.25 (0.94, 1.66) 0.13
 Rectal cancer, n = 351
  Person-years 330 798 737 325   
  Number of CRC-related deaths 28 39 51 17   
  HR (95 % CI)c 1.78 (1.06, 3.00) 1 (Ref) 1.21 (0.78, 1.87) 0.76 (0.40, 1.44) 0.95 (0.74, 1.23) 0.70
WOMEN
 CRC, n = 895
  Person-years 1049 1562 2034 646   
  Number of CRC-related deaths 72 91 119 44   
  HR (95 % CI)c 1.14 (0.82, 1.59) 1 (Ref) 1.33 (1.01, 1.76) 1.41 (0.97, 2.05) 1.18 (1.01, 1.37) 0.03
 Colon cancer, n = 608
  Person-years 670 1124 1270 473   
  Number of CRC-related deaths 49 53 85 30   
  HR (95 % CI)c 1.34 (0.88, 2.02) 1 (Ref) 1.54 (1.08, 2.20) 1.64 (1.03, 2.63) 1.22 (1.02, 1.45) 0.03
 Proximal colon cancer, n = 383
  Person-years 423 673 645 247   
  Number of CRC-related deaths 32 33 50 18   
  HR (95 % CI)c 1.28 (0.76, 2.16) 1 (Ref) 1.59 (1.01, 2.49) 1.49 (0.81, 2.75) 1.18 (0.95, 1.47) 0.14
 Distal colon cancer, n = 207
  Person-years 231 449 579 197   
  Number of CRC-related deaths 15 18 29 12   
  HR (95 % CI)c 1.52 (0.71, 3.25) 1 (Ref) 1.34 (0.69, 2.60) 2.99 (1.27, 7.05) 1.40 (1.01, 1.95) 0.04
 Rectal cancer, n = 283
  Person-years 379 438 721 173   
  Number of CRC-related deaths 23 37 34 14   
  HR (95 % CI)c 0.93 (0.52, 1.64) 1 (Ref) 1.00 (0.60, 1.69) 1.29 (0.67, 2.49) 1.12 (0.82, 1.53) 0.49
  1. a Analyses restricted to cases who maintained or gained weight
  2. b Wald P-value for weight gain as continuous variable
  3. c Stratified Cox model (year of diagnosis: < 1990, 1990–1994, 1995–1999, 2000–2004, ≥2005). Adjustment for age at diagnosis, stage of disease at diagnosis (localized, regional, distant), smoking (never, former, or current), physical activity level (sedentary, moderately active, or active), education (≤9, 10–12, or ≥13 years), and initial BMI (continuous)