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Table 2 Treatment modifications

From: Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program

 

FAS population

Dose interruptionsa: n (%)

204 (31.2)

 Reasons: n (%)

  Patient willingness

8 (3.9)

  General health deterioration

29 (14.2)

  Adverse event (treatment-related or not)

173 (84.8)

  Other

9 (4.4)

Dose reduction: n (%)

278 (42.5)

 Reasons: n (%)

  Patient willingness

6 (2.2)

  General health deterioration

66 (23.7)

  Disease progression

2 (0.7)

  Adverse event (treatment-related or not)

226 (81.3)

  Other

20 (7.2)

Any kind of dose modification: n (%)

329 (50.3)

  1. aPermanent or temporary interruption