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Table 3 Subgroup meta-analyses of p53 expression and survival according to histological type, continent and cut-off value

From: Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis

Subgroup N Cases Pooled RR (95 % CI) P value Analytical model Heterogeneity
I2 (%) P value
Histological type
 ESCC only 23 3454 1.32 (1.10–1.57) 0.002 REM 70 < 0.00001
 EAC only 3 242 1.61 (1.05–2.47) 0.03 FEM 16 0.3
Continent
 Asia 22 3372 1.24 (1.04–1.48) 0.02 REM 72 < 0.00001
 Europe and America 9 640 1.54 (1.22–1.94) 0.0003 FEM 30 0.18
Cut-off value
 10 % 20 2949 1.18 (0.96–1.45) 0.12 REM 71 < 0.00001
 None-10 % 12 1113 1.56 (1.35–1.81) < 0.00001 FEM 44 0.05
  1. N number of studies, FEM fixed-effect model, REM random-effect model