Table 3 Subgroup meta-analyses of p53 expression and survival according to histological type, continent and cut-off value
From: Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis
Subgroup | N | Cases | Pooled RR (95Â % CI) | P value | Analytical model | Heterogeneity | |
|---|---|---|---|---|---|---|---|
I2 (%) | P value | ||||||
Histological type | |||||||
 ESCC only | 23 | 3454 | 1.32 (1.10–1.57) | 0.002 | REM | 70 | < 0.00001 |
 EAC only | 3 | 242 | 1.61 (1.05–2.47) | 0.03 | FEM | 16 | 0.3 |
Continent | |||||||
 Asia | 22 | 3372 | 1.24 (1.04–1.48) | 0.02 | REM | 72 | < 0.00001 |
 Europe and America | 9 | 640 | 1.54 (1.22–1.94) | 0.0003 | FEM | 30 | 0.18 |
Cut-off value | |||||||
 10 % | 20 | 2949 | 1.18 (0.96–1.45) | 0.12 | REM | 71 | < 0.00001 |
 None-10 % | 12 | 1113 | 1.56 (1.35–1.81) | < 0.00001 | FEM | 44 | 0.05 |