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Table 3 Chemotherapy related toxicities. Rates of selected chemotherapy-related toxicities experienced by patients in the fasting cohorts, with CTC adverse event v4.0 grading. Only the grades for which events occurred are shown

From: Safety and feasibility of fasting in combination with platinum-based chemotherapy

Toxicity 24 h 48 h 72 h
# (%) # (%) # (%)
N = 6 N = 7 N = 7
Constitutional/General
 Fatigue Grade 1 or 2 6 (100 %) 5 (71 %) 6 (86 %)
 Alopecia Grade 1 6 (100 %) 5 (71 %) 7 (100 %)
 Gastrointestinal
 Nausea Grade 1 or 2 6 (100 %) 6 (86 %) 3 (43 %)
 Vomiting Grade 1 or 2 5 (83 %) 3 (43 %) 0
 Constipation Grade 1 or 2 3 (50 %) 2 (28 %) 3 (43 %)
 Diarrhea Grade 1 or 2 2 (33 %) 0 4 (57 %)
Grade 3 0 1 (14 %) 0
 Hematologic
 Neutropenia Grade 1 or 2 1 (17 %) 3 (43 %) 1 (14 %)
Grade 3 or 4 4 (67 %) 1 (14 %) 2 (29 %)
 Thrombocytopenia Grade 1 or 2 4 (67 %) 1 (14 %) 1 (14 %)
Grade 3 or 4 0 1 (14 %) 0
 Laboratory/Metabolic
 Hyponatremia Grade 1 1 (17 %) 1 (14 %) 1 (14 %)
Grade 3 1 (17 %) 0 0
 Hypokalemia Grade 1 1 (17 %) 2 (28 %) 0
 Hyperglycemia Grade 1 or 2 4 (67 %) 1 (14 %) 0
 Elevated AST/ALT Grade 1 4 (67 %) 0 3 (43 %)
 Neurologic
 Peripheral Neuropathy Grade 1 3 (50 %) 1 (14 %) 1 (14 %)
 Dizziness Grade 1 or 2 1 (17 %) 5 (71 %) 2 (29 %)