Fig. 4

Graph highlighting the percentage of DNA damage induced by each compound at the major G-rich sites in the PvuII-cleaved pUC19/T7 sequence. The percentage of overall DNA damage is plotted on the y axis and the nine major G-rich sites plotted on the x axis. The percentage of DNA damage was determined for each compound at sites in the sequence containing at least three or more consecutive guanine bases. The total percentage of DNA damage at each G-rich site was calculated from the sum of the percentage of DNA damage at each individual base within the G-rich site. The error bars represent the SEM, determined from three separate experiments. Note that the T1 and T2 sites have been omitted as the DNA damage at these sites was unreadable due to artifact peaks present in the DMF control