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Table 6 IPA top networks

From: Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6

ID Molecules in network Score Focus molecules Top diseases and functions
1 14-3-3, 60S ribosomal subunit, Actin, Alpha tubulin, DNAJB1, ERK1/2, GNB2L1, H2AFX, H2AFZ, Histone h3, HNRNPM, HSP, HSP70, Hsp90, HSPA6, HSPA1L, HSPB1, HSPE1, HSPH1, LDHB, PDIA4, PPIB, 40S ribosomal subunit, Rnr, RPL17, RPL24, RPL26, RPS3, RPS11, RPS27, SYNCRIP, TUBA1B, UBC, YWHAE, YWHAZ 67 26 Protein Synthesis, Cellular Compromise, Cellular Function and Maintenance
2 Akt, ARHGAP28, CD3, CDH22, DPYSL5, EEF1D, GFPT2, HIST1H2AC, HIST1H2AD, HIVEP3, HMGN2, HSF1, HSPA7, Immunoglobulin, Jnk, NFkB (complex), Olfr1508, OTULIN, p85 (pik3r), Pkc(s), PSEN1, RELA, RNF25, RNF141, RNF19B, SEC14L2, SLC6A1, SNRPD3, TCR, TMOD2, TSTA3, VDAC3, ZFAND5, ZFAND6, ZNF274 12 6 Cell-To-Cell Signaling and Interaction, Nervous System Development and Function, Cell Signaling
  1. The table lists the two major protein networks (score >10) related to D6 activity on MM cells identified by IPA analysis. Networks are scored based on the number of dataset molecules they contain (“Focus molecules” column). The higher the score, the lower the probability of finding the observed number of dataset molecules in a given network by random chance. Molecules observed in this study are reported in bold characters in the column “molecules in network”