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Table 2 Patient characteristics of LCRC and RCRC

From: Primary tumor site is a useful predictor of cetuximab efficacy in the third-line or salvage treatment of KRAS wild-type (exon 2 non-mutant) metastatic colorectal cancer: a nationwide cohort study

 

Total

RCRC

LCRC

 
 

N (%)

N (%)

N (%)

P value

Patient Number

901 (100.0)

136 (100.0)

765 (100.0)

 

Gender

 Male

557 (61.8)

74 (54.4)

483 (63.1)

.0536

 Female

344 (38.2)

62 (45.6)

282 (36.9)

 

Mean age at treatment (years)

 Mean (SD)

59.95 (12.02)

61.39 (11.91)

59.70 (12.02)

.0992

 Median (min, max)

60 (22, 96)

61 (22, 96)

60 (26, 90)

 

Age group (years)

<50

163 (18.1)

18 (13.2)

145 (19.0)

.2256

50-64

420 (46.6)

64 (47.1)

356 (46.5)

 

65+

318 (35.3)

54 (39.7)

264 (34.5)

 

Histology

 Mucinous adenocarcinoma

36 (4.0)

15 (11.0)

21 (2.7)

< .0001

 Non-mucinous adenocarcinoma

836 (92.8)

115 (84.6)

721 (94.2)

 

 Others

29 (3.2)

6 (4.4)

23 (3.0)

 

Grade

 1

43 (4.8)

5 (3.7)

38 (5.0)

.0002

 2

689 (76.5)

90 (66.2)

599 (78.3)

 

 3

93 (10.3)

28 (20.6)

65 (8.5)

 

Undifferentiated or Unknown

76 (8.4)

13 (9.6)

63 (8.2)

 

Stage at diagnosisa

 I-III

396 (44.0)

64 (47.1)

332 (43.4)

.4281

 IV

505 (56.0)

72 (52.9)

433 (56.6)

 

Cetuximab combination with chemotherapy

893 (99.1)

135 (99.3)

758 (99.1)

 

Chemotherapy after end of cetuximab

495 (54.9)

61 (44.9)

434 (56.7)

 

Death

747 (82.9)

121 (89.0)

626 (81.8)

 

Follow-up (months)

 Mean (SD)

13.0 (8.6)

10.1 (8.0)

13.5 (8.6)

 

 Median (min, max)

11.5 (0.1, 39.4)

8.1 (1.2, 34.8)

12.5 (0.1, 39.4)

 
  1. Abbreviation: SD standard deviation
  2. aby American Joint Cancer Committee on Cancer (AJCC) system, 6th edition