Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer

Table 1 Relationship between H. pylori infection, COX-2 and beta-catenin expression, and clinicopathological features in gastric cancer

Parameters	N	H. pylori-positive	H. pylori-negative	P value
Age/year
< 65	66	25	41	>0.05
> 65	40	14	26	>0.05
Sex
Male	68	27	41	>0.05
Female	38	12	26	>0.05
T classification
T_1–2	36	8	28	<0.05
T_3–4	70	31	39	<0.05
Lymph node metastasis
Yes	76	33	43	<0.05
No	30	6	24	<0.05
TNM stage
I II	37	8	29	<0.05
III IV	69	31	38	<0.05
COX-2 expression
Low	35	5	30	<0.01
High	71	34	37	<0.01
Beta-catenin expression
Low	41	7	34	<0.01
High	65	32	33	<0.01

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