Genetic polymorphism rs3760396 of the chemokine (C-C motif) ligand 2 gene (CCL2) associated with the susceptibility of lung cancer in a pathological subtype-specific manner in Han-ancestry Chinese: a case control study

Table 4 Association of CCL2 rs3760396 polymorphism with pathological subtypes of lung cancer

Genetic model	Comparison	RRR^a vs. controls	p-value	95 % CI_Lower	95 % CI_Upper
Adenosquamous carcinoma
allelic	G vs C	5.29	< 0.001*	2.40	11.66
Dominant	GC/GG vs CC	9.88	< 0.001*	3.61	27.00
genotypic	GC vs CC	10.73	< 0.001*	3.88	29.71
Adenocarcinoma
allelic	G vs C	1.33	0.16	0.90	1.98
Dominant	GC/GG vs CC	1.29	0.25	0.84	1.99
genotypic	GC vs CC	1.22	0.39	0.78	1.90
	GG vs CC	2.89	0.16	0.66	12.62
Squamous cell carcinoma
allelic	G vs C	0.82	0.48	0.47	1.43
Dominant	GC/GG vs CC	0.79	0.43	0.43	1.43
genotypic	GC vs CC	0.76	0.39	0.41	1.41
	GG vs CC	1.26	0.84	0.13	12.51

^aRRR relative risk ratio; *p < 0.05. CCL2 chemokine (C-C motif) ligand 2 gene, CI confidence interval

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