Fig. 6
From: MEK5 overexpression is associated with the occurrence and development of colorectal cancer
Silencing of MEK5 significantly inhibited cancer growth in vivo. a KD cells (5 × 106 in 0.1 ml of PBS) were injected subcutaneously into the left dorsal flank of each BALB/C nude mice, while the same number of BC cells injected subcutaneously into the right dorsal flank. b Tumor mass volume was measured every two days from day 7 to day 21. On day 21 the six mice were sacrificed and all tumors were harvested. c Silencing of MEK5 could significantly inhibited the cancer growth, when compared with BC cells (P < 0.05). d Western blot assay showed MEK5 protein expression of the xenograft tumors of KD cells was significantly inhibited comparing with that of NC cells. NC, negative control; KD, knockdown