Table 6 Incidence rate of BCC and AK by age at metastatic melanoma diagnosisa
Outcome | 18– < 65 y | 65– < 75 y | 75- < 85 y | 85+ y | ||||
|---|---|---|---|---|---|---|---|---|
Nb | Rate (95 % CI) | N | Rate (95 % CI) | N | Rate (95 % CI) | N | Rate (95 % CI) | |
Among all patients (n = 2810 c , regardless of whether they had a history or pre-existing skin lesion) | ||||||||
BCC | ||||||||
Within 30 d after the index date | 7 | 59.4 (28.3-124.5) | 2 | 39.5 (9.9-158.1) | 2 | 46.8 (11.7-187.1) | 4 | 291.2 (109.3-775.9) |
Within 60 d after the index date | 11 | 47.9 (26.5-86.5) | 3 | 30.5 (9.8-94.6) | 8 | 97.3 (48.6-194.5) | 4 | 151.9 (57.0-404.8) |
Within 90 d after the index date | 11 | 32.8 (18.1-59.3) | 6 | 41.8 (18.8-93.1) | 8 | 66.8 (33.4-133.5) | 5 | 131.8 (54.8-316.6) |
Within 180 d after the index date | 17 | 27.2 (16.9-43.8) | 13 | 49.1 (28.5-84.5) | 12 | 55.0 (31.2-96.8) | 8 | 118.1 (59.0-236.1) |
Within 270 d after the index date | 19 | 21.7 (13.8-34.0) | 16 | 43.4 (26.6-70.9) | 16 | 52.6 (32.2-85.9) | 8 | 87.3 (43.7-174.6) |
Within 365 d after the index date | 21 | 18.9 (12.4-29.1) | 20 | 43.3 (27.9-67.1) | 19 | 49.4 (31.5-77.4) | 8 | 71.0 (35.5- 142.0) |
Ever post index date | 52 | 13.2 (10.0-17.3) | 36 | 26.4 (19.1-36.6) | 36 | 32.3 (23.3-44.8) | 16 | 69.8 (42.7-113. 9) |
AK | ||||||||
Within 30 d after the index date | 2 | 16.9 (4.2-67.6) | 3 | 59.4 (19.1-184.0) | 1 | 23.4 (3.3-165.9) | 1 | 72.5 (10.2-515.0) |
Within 60 d after the index date | 2 | 8.7 (2.2-34.7) | 5 | 51.0 (21.2-122.4) | 4 | 48.4 (18.2-129.0) | 2 | 75.3 (18.8-301.3) |
Within 90 d after the index date | 3 | 8.9 (2.9-27.6) | 6 | 41.9 (18.8-93.2) | 6 | 49.8 (22.4-110.9) | 2 | 52.1 (13.0-208.3) |
Within 180 d after the index date | 3 | 4.8 (1.5-14.8) | 10 | 37.7 (20.3-70.1) | 6 | 27.3 (12.3-60.7) | 3 | 43.3 (14.0-134.4) |
Within 270 d after the index date | 4 | 4.5 (1.7-12.1) | 13 | 35.2 (20.4-60.5) | 11 | 35.8 (19.8-64.7) | 5 | 53.5 (22.3-128.5) |
Within 365 d after the index date | 6 | 5.4 (2.4-11.9) | 16 | 34.4 (21.1-56.1) | 14 | 35.9 (21.3-60.6) | 5 | 43.5 (18.1-104.5) |
Ever post index date | 27 | 6.7 (4.6-9.7) | 33 | 23.6 (16.8-33.3) | 22 | 19.2 (12.6-29.2) | 9 | 36.3 (18.9-69.7) |
Among patients, who had no history or pre-existing skin lesion (n = 2496) | ||||||||
BCC | ||||||||
Within 30 d after the index date | 4 | 36.0 (13.5-96.0) | 2 | 45.5 (11.4-181.8) | 2 | 56.9 (14.2-227.5) | 2 | 198.0 (49.5-791.8) |
Within 60 d after the index date | 6 | 27.7 (12.5-61.7) | 2 | 23.4 (5.8-93.4) | 4 | 58.8 (22.1-156.8) | 2 | 102.9 (25.7-411.6) |
Within 90 d after the index date | 6 | 19.0 (8.5-42.3) | 3 | 24.0 (7.7-74.4) | 4 | 40.2 (15.1-107.2) | 2 | 71.4 (17.9-285.6) |
Within 180 d after the index date | 9 | 15.3 (8.0-29.4) | 7 | 30.2 (14.4-63.3) | 6 | 32.8 (14.8-73.1) | 2 | 39.8 (10.0- 159.3) |
Within 270 d after the index date | 9 | 10.9 (5.7-21.0) | 9 | 27.8 (14.5-53.5) | 7 | 27.4 (13.1-57.5) | 2 | 29.4 (7.3-117.4) |
Within 365 d after the index date | 11 | 10.5 (5.8-19.0) | 9 | 22.1 (11.5-42.5) | 8 | 24.6 (12.3-49.3) | 2 | 23.8 (6.0-95.1) |
Ever post index date | 36 | 9.6 (6.9-13.3) | 19 | 15.5 (9.9-24.3) | 17 | 17.4 (10.8-28.0) | 5 | 28.0 (11.7-67.4) |
AK | ||||||||
Within 30 d after the index date | 2 | 18.0 (4.5-71.9) | 2 | 45.5 (11.4-181.9) | 0 | -- | 0 | -- |
Within 60 d after the index date | 2 | 9.2 (2.3-36.9) | 3 | 35.1 (11.3-108.8) | 3 | 44.0 (14.2-136.4) | 0 | |
Within 90 d after the index date | 2 | 6.3 (1.6-25.3) | 3 | 24.0 (7.7-74.4) | 5 | 50.2 (20.9-120.7) | 0 | -- |
Within 180 d after the index date | 2 | 3.4 (0.8-13.6) | 5 | 21.6 (9.0-51.9) | 5 | 27.4 (11.4-65.7) | 1 | 19.6 (2.8-139.4) |
Within 270 d after the index date | 3 | 3.6 (1.2- 11.2) | 7 | 21.6 (10.3-45.4) | 8 | 31.3 (15.6-62.6) | 1 | 14.5 (2.0-103.1) |
Within 365 d after the index date | 5 | 4.8 (2.0-11.4) | 8 | 19.6 (9.8-39.2) | 9 | 27.7 (14.4-53.2) | 1 | 11.8 (1.7- 83.7) |
Ever post index date | 18 | 4.7 (3.0-7.4) | 21 | 17.0 (11.1-26.1) | 11 | 11.9 (6.1-20.0) | 3 | 16.2 (5.2-50.3) |