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Table 6 Incidence rate of BCC and AK by age at metastatic melanoma diagnosisa

From: The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

Outcome 18– < 65 y 65– < 75 y 75- < 85 y 85+ y
  Nb Rate (95 % CI) N Rate (95 % CI) N Rate (95 % CI) N Rate (95 % CI)
Among all patients (n = 2810 c , regardless of whether they had a history or pre-existing skin lesion)
BCC
 Within 30 d after the index date 7 59.4 (28.3-124.5) 2 39.5 (9.9-158.1) 2 46.8 (11.7-187.1) 4 291.2 (109.3-775.9)
 Within 60 d after the index date 11 47.9 (26.5-86.5) 3 30.5 (9.8-94.6) 8 97.3 (48.6-194.5) 4 151.9 (57.0-404.8)
 Within 90 d after the index date 11 32.8 (18.1-59.3) 6 41.8 (18.8-93.1) 8 66.8 (33.4-133.5) 5 131.8 (54.8-316.6)
 Within 180 d after the index date 17 27.2 (16.9-43.8) 13 49.1 (28.5-84.5) 12 55.0 (31.2-96.8) 8 118.1 (59.0-236.1)
 Within 270 d after the index date 19 21.7 (13.8-34.0) 16 43.4 (26.6-70.9) 16 52.6 (32.2-85.9) 8 87.3 (43.7-174.6)
 Within 365 d after the index date 21 18.9 (12.4-29.1) 20 43.3 (27.9-67.1) 19 49.4 (31.5-77.4) 8 71.0 (35.5- 142.0)
 Ever post index date 52 13.2 (10.0-17.3) 36 26.4 (19.1-36.6) 36 32.3 (23.3-44.8) 16 69.8 (42.7-113. 9)
AK         
 Within 30 d after the index date 2 16.9 (4.2-67.6) 3 59.4 (19.1-184.0) 1 23.4 (3.3-165.9) 1 72.5 (10.2-515.0)
 Within 60 d after the index date 2 8.7 (2.2-34.7) 5 51.0 (21.2-122.4) 4 48.4 (18.2-129.0) 2 75.3 (18.8-301.3)
 Within 90 d after the index date 3 8.9 (2.9-27.6) 6 41.9 (18.8-93.2) 6 49.8 (22.4-110.9) 2 52.1 (13.0-208.3)
 Within 180 d after the index date 3 4.8 (1.5-14.8) 10 37.7 (20.3-70.1) 6 27.3 (12.3-60.7) 3 43.3 (14.0-134.4)
 Within 270 d after the index date 4 4.5 (1.7-12.1) 13 35.2 (20.4-60.5) 11 35.8 (19.8-64.7) 5 53.5 (22.3-128.5)
 Within 365 d after the index date 6 5.4 (2.4-11.9) 16 34.4 (21.1-56.1) 14 35.9 (21.3-60.6) 5 43.5 (18.1-104.5)
 Ever post index date 27 6.7 (4.6-9.7) 33 23.6 (16.8-33.3) 22 19.2 (12.6-29.2) 9 36.3 (18.9-69.7)
Among patients, who had no history or pre-existing skin lesion (n = 2496)
BCC         
 Within 30 d after the index date 4 36.0 (13.5-96.0) 2 45.5 (11.4-181.8) 2 56.9 (14.2-227.5) 2 198.0 (49.5-791.8)
 Within 60 d after the index date 6 27.7 (12.5-61.7) 2 23.4 (5.8-93.4) 4 58.8 (22.1-156.8) 2 102.9 (25.7-411.6)
 Within 90 d after the index date 6 19.0 (8.5-42.3) 3 24.0 (7.7-74.4) 4 40.2 (15.1-107.2) 2 71.4 (17.9-285.6)
 Within 180 d after the index date 9 15.3 (8.0-29.4) 7 30.2 (14.4-63.3) 6 32.8 (14.8-73.1) 2 39.8 (10.0- 159.3)
 Within 270 d after the index date 9 10.9 (5.7-21.0) 9 27.8 (14.5-53.5) 7 27.4 (13.1-57.5) 2 29.4 (7.3-117.4)
 Within 365 d after the index date 11 10.5 (5.8-19.0) 9 22.1 (11.5-42.5) 8 24.6 (12.3-49.3) 2 23.8 (6.0-95.1)
 Ever post index date 36 9.6 (6.9-13.3) 19 15.5 (9.9-24.3) 17 17.4 (10.8-28.0) 5 28.0 (11.7-67.4)
AK         
 Within 30 d after the index date 2 18.0 (4.5-71.9) 2 45.5 (11.4-181.9) 0 -- 0 --
 Within 60 d after the index date 2 9.2 (2.3-36.9) 3 35.1 (11.3-108.8) 3 44.0 (14.2-136.4) 0  
 Within 90 d after the index date 2 6.3 (1.6-25.3) 3 24.0 (7.7-74.4) 5 50.2 (20.9-120.7) 0 --
 Within 180 d after the index date 2 3.4 (0.8-13.6) 5 21.6 (9.0-51.9) 5 27.4 (11.4-65.7) 1 19.6 (2.8-139.4)
 Within 270 d after the index date 3 3.6 (1.2- 11.2) 7 21.6 (10.3-45.4) 8 31.3 (15.6-62.6) 1 14.5 (2.0-103.1)
 Within 365 d after the index date 5 4.8 (2.0-11.4) 8 19.6 (9.8-39.2) 9 27.7 (14.4-53.2) 1 11.8 (1.7- 83.7)
 Ever post index date 18 4.7 (3.0-7.4) 21 17.0 (11.1-26.1) 11 11.9 (6.1-20.0) 3 16.2 (5.2-50.3)
  1. aAbbreviation: BCC, basal cell carcinoma; AK, actinic keratosis. Incidence rate, per 1000 person-years
  2. bNumber of events
  3. cThe analysis was conducted among 2810 patients, because 4 patients died on the index date and were excluded