Table 3 Summary of findings in our review on incidence and characteristics of patients with brain metastases from colorectal cancer
From: Systematic review: brain metastases from colorectal cancer—Incidence and patient characteristics
All studies | Studies with CRC patients eligible for data pooling | ||||||
|---|---|---|---|---|---|---|---|
No. studies | Range | No. studies | No. CRC Patients | No. BM patients | Range | Weighted mean (95 % CI) | |
Incidence of BM | 36 | 0.4–23 % | 16 | 100,825 | 1588 | 0.6–2.7 % | 1.55 % (1.48–1.63 %) |
Characteristics of BM patients | |||||||
ᅟMedian age (years) | 20 | 55.7–73 | 7 | 52,591 | 716 | 55.7–73 | |
ᅟMedian BMFI (months) | 28 | 20–40 | 11 | 56,618 | 794 | 21–34.3 | |
ᅟMale | 37 | 39–80 % | 14 | 100,105 | 1578 | 44–80 % | 57.2 % (54.7–59.8 %) |
ᅟStage of primary disease | 25 | 12 | 48,556 | 673 | |||
ᅟ- Stage 1 | 21 | 0–11 % | 11 | 43,211 | 531 | 0–11 % | 1.3 % (0.5–2.8 %) |
ᅟ- Stage 2 | 20 | 0–33 % | 11 | 43,211 | 531 | 0–33 % | 17.5 % (14.1–21.2 %) |
ᅟ- Stage 3 | 22 | 17–77 % | 11 | 43,211 | 531 | 32–77 % | 46.6 % (41.9–51.2 %) |
ᅟ- Stage 4 | 24 | 8–56 % | 12 | 48,556 | 673 | 8–51 % | 36.2 % (32.3–40.3 %) |
ᅟRectal primary | 31 | 14–71 % | 13 | 57,288 | 799 | 20–67 % | 48.5 % (44.9–52.0 %) |
ᅟExtracranial metastases | 31 | 5–100 % | 11 | 55,840 | 779 | 77–100 % | 87.7 % (85.1–90.1 %) |
ᅟLung metastases | 32 | 36–92 % | 11 | 52,399 | 783 | 51–86 % | 68.6 % (65.0–72.0 %) |
ᅟLiver metastases | 28 | 22–80 % | 10 | 50,671 | 734 | 24–80 % | 40.6 % (36.8–44.5 %) |